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Skyrizi vs. Enbrel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Enbrel (etanercept) are both injectable medications used to treat autoimmune conditions, but they have some key differences. Skyrizi is an interleukin antagonist that targets IL-23 to reduce inflammation, while Enbrel is a TNF inhibitor that blocks TNF proteins to achieve a similar effect. Skyrizi is typically administered every 2 to 3 months after initial doses, whereas Enbrel requires weekly injections. Skyrizi is used for plaque psoriasis, psoriatic arthritis, and Crohn's disease, while Enbrel is approved for rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. Enbrel can be used in children as young as 2 years old for certain conditions, but Skyrizi is only approved for adults. Both medications can increase the risk of infections, but Enbrel also has warnings about potential cancer risks and nervous system effects.

Skyrizi

(risankizumab)

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Enbrel

(etanercept)

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Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after a couple of starter doses (depends on your condition)
  • Can give injections under the skin at home after you get trained

Cons

  • Must be given as an injection
  • Not approved for children

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Summary for Enbrel

Prescription only

Enbrel (etanercept) is a weekly injection used for many autoimmune conditions. Currently, it's only available as a brand-name product and can be expensive.

Indications for Enbrel

  • Rheumatoid arthritis (RA)
  • Plaque psoriasis (PsO) and psoriatic arthritis (PsA)
  • Ankylosing spondylitis (AS)
  • Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

Pros and Cons for Enbrel

Pros

  • Available in a prefilled syringe or autoinjector for easy-at-home injections
  • Can be used in children age 2 and older for certain indications (JIA)
  • Can be kept at room temperature for up to 14 days
  • Manufacturer offers copay card for people with commercial insurance
  • Not many side effects other than infection and redness and irritation at the injection site

Cons

  • Raises risk of serious infections
  • Can cause the hepatitis B virus to reappear if you have a history of infection
  • Lymphoma and other cancers have been reported in people taking Enbrel (etanercept)
  • Available only as a brand medication so it can be expensive and isn't always covered by insurance
  • Needs to be given every week, unlike Humira (adalimumab), which is given every other week

Common Side Effects for Enbrel

  • Infection (including common cold/flu) (50%)
  • Injection site reaction (37%)
  • Diarrhea (8%)

Warnings for Enbrel

  • Serious infections
  • Cancers
  • Nervous system effects
  • Heart failure
  • Bleeding and infections

Prices with our coupons for Skyrizi vs. Enbrel

Price Card Drug Icon
Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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Price Card Drug Icon
Enbrel1 carton / 4 sureclicks of 50mg
$3,353.53$11,050.23
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