Key takeaways
Jardiance (empagliflozin) and Janumet (sitagliptin/metformin) are both medications used to manage Type 2 diabetes, but they work in different ways and have distinct characteristics. Jardiance is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that helps lower blood sugar by causing your body to remove excess sugar through urine. It is taken once daily and can also reduce the risk of heart failure and chronic kidney disease complications. Janumet combines two medications: sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. It works by improving insulin function and reducing sugar production and absorption in the body. Janumet is taken either twice daily (immediate-release) or once daily (extended-release). Jardiance is currently only available as a brand-name medication, with generics expected by 2025, while Janumet will have generics available by 2026. Common side effects of Jardiance include urinary tract infections and yeast infections, whereas Janumet often causes diarrhea and upper respiratory tract infections. Both medications can be taken together for better blood sugar control, but you should always consult your healthcare provider for personalized advice.
