Key takeaways
Sumatriptan (Imitrex) and topiramate (Topamax) are both used to manage migraines, but they work differently and have different uses. Sumatriptan is a triptan that treats migraines by tightening blood vessels and reducing inflammation. It's taken as needed when a migraine starts and can be taken again after 2 hours if needed, but not more than twice in 24 hours. Topiramate, on the other hand, is an antiepileptic that prevents migraines and treats seizures. It's taken daily, either once or twice, depending on the form. Sumatriptan is available as a lower-cost generic, while topiramate also comes in generic forms and various formulations, including tablets, capsules, and a liquid. Sumatriptan can cause heart problems and serotonin syndrome, while topiramate can lead to kidney stones, vision problems, and high blood acid levels. Both medications interact with other drugs, so it's important to discuss all your medications with your prescriber.
