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Trelegy Ellipta Coupon - Trelegy Ellipta 60 blisters of 100mcg/62.5mcg/25mcg inhaler

Trelegy Ellipta

fluticasone / umeclidinium / vilanterol
Used for Asthma, COPD
Used for Asthma, COPD

Trelegy Ellipta is a combination maintenance inhaler used to treat adults with chronic obstructive pulmonary disease (COPD) and asthma. It contains three active ingredients: fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). Together, these help reduce airway inflammation, relax airway muscles, and help keep your airways open. The typical dose is one puff inhaled through the mouth once a day. Common side effects include headache, cough, and back pain.

Last reviewed on July 3, 2025
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$832.82(save 19.68%)
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$668.91
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basics-icon

What is Trelegy Ellipta?

What is Trelegy Ellipta used for?

How Trelegy Ellipta works

Trelegy Ellipta is a combination of three medications that work together to help you breathe easier.

When does Trelegy Ellipta start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsTrelegy Ellipta
Drug ClassICS / LAMA / LABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Trelegy Ellipta essentials

basics-icon

What are the side effects of Trelegy Ellipta?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

COPD:
  • Headache (4%)
  • Back pain (4%)
  • Changes in taste (2%)
  • Diarrhea (2%)
Asthma:

Other Side Effects

COPD:
  • Cough
  • Mouth and throat pain
  • Oral thrush
  • Upper respiratory tract infection
  • Stomach flu
  • Bronchitis
  • Flu
  • Urinary tract infections (UTI)
  • Constipation
  • Joint pain
  • Hoarseness
Asthma:
  • Urinary tract infection (UTI)
  • Voice changes
  • Mouth and throat pain
  • Cough
  • Runny nose
  • Hoarseness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Pneumonia: more mucus, mucus changing color, fever, chills, coughing more than usual, more trouble breathing
  • Serious allergic reaction: rash, hives, swelling of your face or tongue, difficulty breathing
  • Sudden narrowing of the airways: worsening trouble breathing, coughing, wheezing
  • Heart problems: a fast or irregular heartbeat, feeling your heartbeat, chest pain
  • Eye problems: eye pain, nausea or vomiting, blurred vision, seeing halos or bright colored lights, red eyes
When do Trelegy Ellipta possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Cough
Sore throat
Risk of respiratory tract infection
Risk of oral thrush
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Muscle pain or cramps
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Thrush—white patches in the mouth
  • Trouble passing urine
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Trelegy Ellipta

thumbs-up

Pros

Only need to inhale one puff once a day

Combination of three medications within a single inhaler

Approved for both COPD and asthma

thumbs-down

Cons

Common side effects include headache and cough

Can't use if severely allergic to milk proteins because it contains lactose

Need to rinse your mouth after each dose to prevent oral thrush

pharmacist-tips

Pharmacist tips for Trelegy Ellipta

pharmacist
  • Use Trelegy Ellipta once a day at the same time every day to prevent COPD or asthma attacks. You can use it at any time of the day, but using it daily helps it work best.

    • Trelegy Ellipta won't help during sudden breathing problems. If you have a COPD or asthma attack, use a rescue inhaler like albuterol if you have sudden trouble breathing for fast relief.

      • Contact your pulmonologist right away if Trelegy Ellipta doesn’t seem to work as well, if you need more doses than usual, or if your breathing feels worse. These could be signs that your condition isn't under control.

        • Don't start any new medications while using Trelegy Ellipta without asking your pulmonologist or pharmacist first. It can interact with other medications, such as beta blockers or tricyclic antidepressants.

          • Trelegy Ellipta commonly causes upper respiratory tract infections with symptoms like stuffy nose or sore throat. Using a humidifier, drinking fluids, and getting rest might help ease these symptoms.

            • Some people using Trelegy Ellipta might feel side effects like fast heartbeat, chest pain, shakiness, or nervousness. Tell your pulmonologist right away if you notice any of these symptoms.

              • Store Trelegy Ellipta at room temperature in a dry place, away from heat or sunlight. Keep any unused inhalers sealed in the original foil pouch until you're ready to use them.

                • Write use-by date: Once you open the foil tray, write down the use-by date on the inhaler (6 weeks from the day you opened it). Throw away the inhaler when either 6 weeks have passed or the dose counter shows “0”, whichever comes first.

                  • Unlike most inhalers, you don't need to prime or shake Trelegy Ellipta. EEach time you open the cover, it gets one dose ready. Only open it when you’re ready to take your medicine.

                    • Taking a dose: When you're ready to take your dose, slide the cover until it clicks. Breathe out fully, away from the inhaler.

                      • Place the mouthpiece in your mouth and take a long, steady, deep breath in. Then try to hold your breath for 3 to 4 seconds, or as long as is comfortable, to help the medication reach deep into your lungs.

                        • After use: Rinse your mouth with water and then spit it out. This helps lower your chance of getting a mouth or throat infection called oral thrush.

                          • Cleaning: Never wash the inhaler with water or any liquid. Instead, clean the mouthpiece every once in a while by wiping it with a dry cloth. Water or moisture can clog the inhaler and keep the medication from coming out properly.

                            More on Trelegy Ellipta tips

                            faqs

                            Frequently asked questions about Trelegy Ellipta

                            How long does it take for Trelegy Ellipta to work?
                            When you first start using Trelegy Ellipta, you might notice your breathing improves within 15 minutes of taking a dose. But it can take a few weeks for the medication to fully control your symptoms. If you don’t feel better after a few weeks, talk to your pulmonologist to see if any changes are needed.
                            Is Trelegy Ellipta a steroid?
                            Yes, Trelegy Ellipta contains an inhaled corticosteroid called fluticasone. This medication helps to reduce inflammation in your lungs, which makes it easier to breathe.
                            Can Trelegy Ellipta cause hair loss?
                            Hair loss wasn't reported as a side effect in clinical studies of Trelegy Ellipta. If you do notice hair loss while using this medication, talk to your prescriber — they can help you explore possible causes and recommend next steps.
                            How long does Trelegy Ellipta stay in your system?
                            Trelegy Ellipta contains three active ingredients — fluticasone, umeclidinium, and vilanterol — that leave your body at different rates. Vilanterol and umeclidinium have half-lives of about 11 hours, so they’re usually cleared from your system within 2 days. Fluticasone takes longer, with a half-life of about 24 hours, meaning it can take 4 to 5 days to fully leave your body. But this can vary depending on your liver health, dose, and any other medications you're taking.
                            Can I take Trelegy Ellipta with albuterol?
                            Your pulmonologist will likely prescribe albuterol as a rescue inhaler when you're using Trelegy Ellipta. That's because Trelegy Ellipta is a long-acting medication that helps control your asthma or COPD over time but won’t work fast during a sudden breathing problem. A rescue inhaler like albuterol works quickly to open your airways and can relieve symptoms like coughing, wheezing, or shortness of breath.
                            Does Trelegy Ellipta cause weight gain?
                            People who took Trelegy Ellipta in clinical studies didn't report weight gain as a side effect. If you notice unexpected weight gain while using this medication, talk to your prescriber. They can help figure out what might be causing the change.
                            Is muscle pain a side effect of Trelegy Ellipta?
                            Yes, Trelegy Ellipta can cause muscle pain. Some people reported back pain and muscle spasms while using the medication. Research suggests that muscle pain is linked to vilanterol, the LABA found in Trelegy Ellipta. Additional studies have also linked LABAs to nighttime leg cramps. If you have muscle pain while using this inhaler, talk to your healthcare provider so they can help you manage the symptoms.
                            What's the difference between Breztri and Trelegy Ellipta?
                            Breztri Aerosphere (budesonide / glycopyrrolate / formoterol) and Trelegy Ellipta are both inhalers, but they have some differences. Breztri is FDA approved only for COPD, while Trelegy Ellipta is approved to treat both COPD and asthma. The inhalers have different active ingredients, and how you take them also differs — Breztri is used as two puffs twice a day from a spray inhaler, while Trelegy Ellipta is used as one puff once a day with a dry powder inhaler. Talk to your prescriber to learn about how these two inhalers compare.
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                            warings-icon

                            What are the risks and warnings for Trelegy Ellipta?

                            Trelegy Ellipta can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                            risk-warning

                            Worsening symptoms or sudden flare-ups

                            Trelegy Ellipta isn't made to treat sudden breathing problems. Don’t use it as a rescue inhaler because it won’t work fast enough. Instead, use a short-acting rescue inhaler like albuterol for sudden symptoms such as wheezing or shortness of breath.

                            If you notice you're using your rescue inhaler more often than usual, tell your pulmonologist. This could be a sign that your condition is getting worse. Don’t take extra doses of Trelegy Ellipta — it won’t help and could lead to serious side effects like heart problems, shakiness, or dizziness.

                            risk-warning

                            Overdose

                            • Risk factors: Using too much Trelegy Ellipta | Also using other LABAs

                              Don't use Trelegy Ellipta more often or at higher doses than prescribed. Using too much can lead to serious side effects, including heart problems and, in rare cases, death. Since Trelegy Ellipta already contains a long-acting beta agonist (LABA), don’t use any other inhalers that also have a LABA — such as Serevent Diskus (salmeterol) or Perforomist (formoterol) — while using this medication.

                              risk-warning

                              Oral thrush

                              • Risk factors: Not rinsing and spitting after using Trelegy Ellipta

                                Trelegy Ellipta can sometimes cause a yeast infection in your mouth or throat called oral thrush. If you notice white patches or a cotton-like feeling in your mouth or throat, let your prescriber know — it can usually be treated with antifungal medication. In some cases, your prescriber might have you pause treatment. To help prevent thrush, rinse your mouth with water after each dose, and spit the water out — don’t swallow it.

                                risk-warning

                                Pneumonia

                                • Risk factors: COPD

                                  Trelegy Ellipta might raise your risk of lower respiratory infections, including pneumonia. In rare cases, some of these infections can be serious or even fatal. This risk is especially important to watch for in people with COPD, since pneumonia symptoms can look very similar to a flare-up. Let your care team know right away if you have symptoms like more mucus, mucus changing color, fever, chills, coughing more than usual, more trouble breathing

                                  risk-warning

                                  Risk of infection

                                  • Risk factors: Active, chronic (long-term), or recurrent infection | Medical conditions that weaken the immune system | Taking other medications that can weaken the immune system

                                    Trelegy Ellipta can make it harder for your body to fight infections. Serious infections, like tuberculosis (TB), chickenpox, and measles can be more dangerous if you're using this medication. Don't use Trelegy Ellipta if you have an active infection or an infection that keeps coming back without talking with your prescriber first. Tell your care team right away if you have signs of an infection, like fever, cough, sore throat, muscle aches, or feeling very tired.

                                    risk-warning

                                    Changes in stress hormone levels

                                    • Risk factors: Using Trelegy Ellipta for a long time | Using too much Trelegy Ellipta

                                      When you use Trelegy Ellipta at the right dose, it’s less likely to affect your body’s natural balance of steroid hormones. But if you use too much, or if you're very sensitive to steroids, it can cause problems like high steroid levels or adrenal suppression, which means your body might not make enough of its own steroids. Let your prescriber know if you feel very tired, weak, or sick to your stomach — especially during times of stress or after surgery — as these could be signs of low steroid hormone levels.

                                      If you're switching from oral steroids like prednisone to Trelegy Ellipta, your body might need time to adjust. Oral steroids can weaken your adrenal glands over time, and they might not bounce back right away after you stop. If you’ve been taking high doses of oral steroids, your pulmonologist will help you slowly lower the dose to reduce the risk of side effects.

                                      risk-warning

                                      Sudden narrowing of the airways

                                      Trelegy Ellipta can sometimes cause a sudden tightening of the airways called paradoxical bronchospasm, meaning your breathing might get worse instead of better. This can be dangerous and life-threatening. If you notice more wheezing, coughing, or shortness of breath after using it, stop the medication right away and contact your prescriber.

                                      risk-warning

                                      Serious allergic reaction

                                      • Risk factors: Severe allergy to milk proteins (lactose)

                                        Serious allergic reactions to Trelegy Ellipta can happen. Get medical help right away if you notice hives, a rash, swelling of face or throat, or trouble breathing. If you have a severe milk protein allergy, don't use Trelegy Ellipta — it contains lactose, which could cause a dangerous reaction.

                                        risk-warning

                                        Heart problems

                                        • Risk factors: History of heart problems | High blood pressure

                                          Trelegy Ellipta might affect your heart, so it should be used with caution if you have conditions like high blood pressure, irregular heartbeat, or a history of heart disease. Tell your prescriber if you notice chest pain, a fast or pounding heartbeat, or dizziness while using this inhaler. They might check your heart regularly to make sure this medication is safe for you.

                                          risk-warning

                                          Weaker bones

                                          • Risk factors: Using Trelegy Ellipta long term | Unable to move for a long period of time | Family history of osteoporosis | Menopause | Tobacco use | Older adults | Poor diet | Taking medications that can cause bone loss

                                            Using Trelegy Ellipta over a long time can cause a small drop in bone strength. This might not always lead to broken bones, but it can be a concern if you have risk factors like being older, going through menopause, smoking, eating poorly, not being active, or taking certain medications.

                                            Since people with COPD often have some of these risk factors, your prescriber might check your bone health before you start using Trelegy Ellipta and from time to time afterward. If your bone strength gets too low but you still need this inhaler, your prescriber might suggest ways to help protect your bones.

                                            risk-warning

                                            Eye problems

                                            • Risk factors: Using Trelegy Ellipta long term

                                              Using Trelegy Ellipta long term can raise your risk of eye problems like glaucoma, high eye pressure, or cataracts. Be on the lookout for symptoms such as eye pain or pressure, blurry vision, red eyes, or seeing halos or bright colors around lights. These could be signs of a serious eye condition. If you notice any of these, contact your prescriber right away. They might send you to an eye specialist to check for problems.

                                              risk-warning

                                              Trouble urinating

                                              • Risk factors: Enlarged prostate | Bladder-neck blockage

                                                Trelegy Ellipta contains a long-acting muscarinic antagonist (LAMA), which is a type of anticholinergic. Anticholinergic medications can sometimes cause trouble urinating, so this medication should be used carefully if you already have trouble emptying your bladder. This includes people with an enlarged prostate or bladder-neck blockage. Let your prescriber know right away if you have signs of urinary retention, such as difficulty urinating or pain with urination. These could be signs of a serious problem that needs medical attention.

                                                risk-warning

                                                Worsening of certain health conditions

                                                • Risk factors: Using too much Trelegy Ellipta | High thyroid hormone | History of seizures

                                                  Speak to your prescriber before using Trelegy Ellipta if you have health conditions like seizures, or high thyroid hormone. This inhaler can sometimes make these conditions worse or lead to serious side effects. Be sure to share your full medical history with your prescriber before starting this medication.

                                                  risk-warning

                                                  Low potassium and high blood sugar

                                                  • Risk factors: Using Trelegy Ellipta too much

                                                    Trelegy Ellipta can sometimes cause low potassium levels or high blood sugar, though this is usually temporary and doesn’t need treatment. But in some cases, low potassium can affect your heart. Let your care team know if you have muscle pain or weakness, muscle cramps, or an irregular heartbeat — these could be signs of low potassium.

                                                    dosage

                                                    Trelegy Ellipta dosage forms

                                                    The average cost for 1 inhaler of 60 blisters of 100mcg/62.5mcg/25mcg of Trelegy Ellipta is $668.96 with a free GoodRx coupon. This is 19.67% off the average retail price of $832.82.
                                                    inhaler
                                                    Inhaler
                                                    DosageQuantityPrice as low asPrice per unit
                                                    60 blisters of 100mcg/62.5mcg/25mcg1 inhaler$668.96$668.96
                                                    60 blisters of 200mcg/62.5mcg/25mcg1 inhaler$668.91$668.91

                                                    Typical dosing for Trelegy Ellipta

                                                    • COPD: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once a day.

                                                    • Asthma: The typical dose is 1 inhalation of 100 mcg/62.5 mcg/25 mcg or 200 mcg/62.5 mcg/25 mcg (fluticasone/umeclidinium/vilanterol) by mouth once a day.

                                                    More on Trelegy Ellipta dosage forms

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                                                    How much does Trelegy Ellipta cost?

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                                                    contraindications-icon

                                                    Trelegy Ellipta contraindications

                                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trelegy Ellipta will not be safe for you to take.
                                                    • Treatment of sudden, severe asthma attacks or COPD flare-ups

                                                    • Severe allergy to milk proteins

                                                    alternatives

                                                    What are alternatives to Trelegy Ellipta?

                                                    There are a number of medications that your doctor can prescribe in place of Trelegy Ellipta. Compare a few possible alternatives below.
                                                    Trelegy Ellipta
                                                    Used for:
                                                    $668.91 Lowest GoodRx priceView Prices
                                                    Used for:
                                                    $656.51 Lowest GoodRx priceView Prices
                                                    Used for:
                                                    • Maintenance treatment of asthma in people ages 5 years and older

                                                    $218.16 Lowest GoodRx priceView Prices
                                                    images

                                                    Trelegy Ellipta images

                                                    white - TRELEGY ELLIPTA 100mcg-62.5mcg-25mcg / actuation Powder for Inhalation
                                                    This medicine is White Inhaler.white - TRELEGY ELLIPTA 100mcg-62.5mcg-25mcg / actuation Powder for Inhalation

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                                                    References

                                                    Best studies we found
                                                    View All References (4)

                                                    Magee, J. S., et al. (2018). Paradoxical Bronchoconstriction with Short-Acting Beta Agonist. American Journal of Case Reports.

                                                    National Heart, Lung, and Blood Institute. (2012). Asthma care quick reference.

                                                    Siler, T. M., et al. (2015). Efficacy and safety of umeclidinium added to fluticasone furoate/vilanterol in chronic obstructive pulmonary disease: Results of two randomized studies. Respiratory Medicine.

                                                    Sussman, R. D., et al. (2019). Primary Bladder Neck Obstruction. Reviews in Urology.

                                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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