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prucalopride
Used for Constipation
Used for Constipation
Prucalopride (Motegrity) is used to treat long-term constipation from an unknown cause in adults. It works as a serotonin-4 receptor agonist to stimulate your gut to move. The medication comes as tablets and the usual dosage is taken by mouth once a day. Common side effects are headache, stomach pain, and nausea.
What is Prucalopride (Motegrity)?
What is Prucalopride (Motegrity) used for?
- Chronic idiopathic constipation (CIC) in adults
How Prucalopride (Motegrity) works
Prucalopride (Motegrity) is a serotonin-4 receptor agonist. It works on proteins called serotonin receptors in your colon. This helps the muscles in your gut contract to push food and waste through your digestive tract. It can help make it easier for stool to pass.
When does Prucalopride (Motegrity) start working?Time passed since treatment started:
Drug facts
| Common Brands | Motegrity |
|---|---|
| Drug Class | Serotonin receptor agonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Prucalopride (Motegrity) essentials
Side effects of Prucalopride (Motegrity)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (19%)
- Stomach pain (16%)
- Nausea (14%)
- Diarrhea (13%)
Less Common Side Effects
- Bloating or a swollen stomach
- Vomiting
- Passing gas
- Dizziness
- Tiredness
Prucalopride (Motegrity) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and behavior
- Severe allergic reaction: shortness of breath, rash, itching, hives, swelling in the face
When do Prucalopride (Motegrity) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Headache
Diarrhea
The following Prucalopride (Motegrity) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Thoughts of suicide or self-harm, worsening mood, feelings of depression
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Get your GoodRx coupon
$649.49
GoodRx discount
$30.31
Pros and cons of Prucalopride (Motegrity)
Pros
- An option for CIC after other treatments haven't worked well enough
- Can start to work to improve CIC symptoms within hours
- Helps normalize the number of complete bowel movements per week
- Taken once a day by mouth
Cons
- Might cause diarrhea and stomach pain
- Rare risk of unusual changes in mood or behavior
- Not safe in people with a gut tear or blockage
- Unknown if it's safe or works well in children
Pharmacist tips for Prucalopride (Motegrity)
- Take prucalopride (Motegrity) by mouth once daily, with or without food.
- Tell your gastroenterologist if you have kidney problems. People with severe kidney problems need a lower dose of prucalopride (Motegrity). When the kidneys don't work well, the medication can build up in the body and raise the risk of side effects.
- Tell your gastroenterologist if you regularly take laxatives. Ask if you should keep taking them after you start prucalopride (Motegrity).
- Diarrhea and headache are common side effects of prucalopride (Motegrity). These side effects usually happen within the first week of treatment. They often go away after a few days. If they don't go away or bother you a lot, talk to your care team.
- Although rare, look out for unusual changes in behavior and mood while taking prucalopride (Motegrity). This can be quite serious. Tell your prescriber right away if you have symptoms of depression. And call 911 or 988 (Suicide and Crisis Lifeline) if you have thoughts of hurting yourself.
- Tell your gastroenterologist and pharmacist about all the medications you take. Prucalopride (Motegrity) might interact with other medications. For example, taking it with other constipation medications can raise your risk of diarrhea. Your care team can make sure your medications are safe to take together.
- To get the most out of prucalopride (Motegrity), there are other things you can do to help prevent constipation. Drink lots of water to stay hydrated. Also eat plenty of fruits and vegetables that are high in fiber. Talk with your gastroenterologist for more tips on preventing and managing constipation.
- Remember to follow up with your gastroenterologist regularly. Based on your bowel habits and symptoms, they can help decide if you still need to take prucalopride (Motegrity).
- Store prucalopride (Motegrity) in its original container. This helps protect the tablets from moisture.
- If you're pregnant or breastfeeding: Tell your gastroenterologist or prescriber. There isn't enough information to know how safe prucalopride (Motegrity) is during pregnancy or while breastfeeding. Your care team can explain the risks and benefits and help you choose a safe treatment option.
Risks and warnings for Prucalopride (Motegrity)
Prucalopride (Motegrity) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Reports of suicidal thoughts and behavior
Some people taking prucalopride (Motegrity) had suicidal thoughts or behavior. Others had new or worsening depression. These problems happened within the first few weeks after starting the medication. It's not clear if prucalopride (Motegrity) caused these mood and behavior changes or if there's a higher risk.
Watch for signs of depression while taking prucalopride (Motegrity). Also look out for any unusual changes in mood or behavior . If you or the people around you notice these changes, stop taking the medication and tell your prescriber right away. If you have thoughts of hurting yourself, call 911 or 988 (the Suicide and Crisis Lifeline) right away.
Prucalopride (Motegrity) dosage
The average cost for 30 tablets of 2mg of of Prucalopride (Motegrity) is $30.31 with a free GoodRx coupon. This is 95.33% off the average retail price of $649.49. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1mg of | 30 tablets | $35.22 | $1.17 |
| 2mg of | 30 tablets | $30.31 | $1.01 |
Typical dosage for Prucalopride (Motegrity)
The typical dose is 2 mg by mouth once a day.
If you have severe kidney problems, the dose is lowered to 1 mg once a day.
How much does Prucalopride (Motegrity) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Prucalopride (Motegrity) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Prucalopride (Motegrity) will not be safe for you to take.
- Intestinal tear or blockage due to:
- Problems related to the gut wall
- Obstructive ileus
- Severe inflammatory conditions of the gut like Crohn's disease, ulcerative colitis, and toxic megacolon/megarectum
What are alternatives to Prucalopride (Motegrity)?
There are a number of medications that your doctor can prescribe in place of Prucalopride (Motegrity). Compare a few possible alternatives below.
News about Prucalopride (Motegrity)
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