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Motegrity vs. Linzess

Prucalopride (Motegrity) is used to treat long-term constipation from an unknown cause in adults. It works as a serotonin-4 receptor agonist to stimulate your gut to move. The medication comes as tablets and the usual dosage is taken by mouth once a day. Common side effects are headache, stomach pain, and nausea.

• Chronic idiopathic constipation (CIC) in adults

• Headache (19%)
• Stomach pain (16%)
• Nausea (14%)
• Diarrhea (13%)

• Reports of suicidal thoughts and behavior

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

• Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
• Chronic idiopathic constipation (CIC) in adults
• Functional constipation (FC) in children 2 years and older

Adults:

• Diarrhea
• Stomach pain
• Having gas
• Bloating and feeling full in the belly

Children:

• Diarrhea

• Not for children under 2 years old because of risk of serious dehydration
• Severe diarrhea