Motegrity vs. Linzess for Constipation: Important Differences and Potential Risks.

Prucalopride

(Motegrity)

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Linzess

(linaclotide)

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Summary for Motegrity

Prescription only

Prucalopride (Motegrity) is used to treat long-term constipation from an unknown cause in adults. It works as a serotonin-4 receptor agonist to stimulate your gut to move. The medication comes as tablets and the usual dosage is taken by mouth once a day. Common side effects are headache, stomach pain, and nausea.

Indications for Motegrity

Chronic idiopathic constipation (CIC) in adults

Pros and Cons for Motegrity

Pros

An option for CIC after other treatments haven't worked well enough
Can start to work to improve CIC symptoms within hours
Helps normalize the number of complete bowel movements per week
Taken once a day by mouth

Cons

Might cause diarrhea and stomach pain
Rare risk of unusual changes in mood or behavior
Not safe in people with a gut tear or blockage
Unknown if it's safe or works well in children

Common Side Effects for Motegrity

Headache (19%)
Stomach pain (16%)
Nausea (14%)
Diarrhea (13%)

Warnings for Motegrity

Reports of suicidal thoughts and behavior

Summary for Linzess

Prescription only

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

Indications for Linzess

Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
Chronic idiopathic constipation (CIC) in adults
Functional constipation (FC) in children 2 years and older

Pros and Cons for Linzess

Pros

Only need to take once a day
Can start to see improvement as early as a week of taking it every day

Cons

Must take on an empty stomach (30 minutes before a meal)
Can cause diarrhea

Common Side Effects for Linzess

Adults:

Diarrhea
Stomach pain
Having gas
Bloating and feeling full in the belly

Children:

Diarrhea

Warnings for Linzess

Not for children under 2 years old because of risk of serious dehydration
Severe diarrhea

Prices with our coupons for Motegrity vs. Linzess

Prucalopride30 tablets / 2mg

$32.46$595.94

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Linzess30 capsules / 145mcg

$283.31$353.38

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Motegrity vs. Linzess

Prucalopride

Linzess

Summary for Motegrity

Indications for Motegrity

Pros and Cons for Motegrity

Pros

Cons

Common Side Effects for Motegrity

Warnings for Motegrity

Summary for Linzess

Indications for Linzess

Pros and Cons for Linzess

Pros

Cons

Common Side Effects for Linzess

Warnings for Linzess

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Prucalopride

Linzess

Summary for Motegrity

Indications for Motegrity

Pros and Cons for Motegrity

Pros

Cons

Common Side Effects for Motegrity

Warnings for Motegrity

Summary for Linzess

Indications for Linzess

Pros and Cons for Linzess

Pros

Cons

Common Side Effects for Linzess

Warnings for Linzess