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Motegrity vs. Linzess

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Prucalopride

(Motegrity)

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Linzess

(linaclotide)

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Summary for Motegrity

Prescription only

Prucalopride (Motegrity) is used to treat long-term constipation from an unknown cause in adults. It works as a serotonin-4 receptor agonist to stimulate your gut to move. The medication comes as tablets and the usual dosage is taken by mouth once a day. Common side effects are headache, stomach pain, and nausea.

Indications for Motegrity

Pros and Cons for Motegrity

Pros

  • An option for CIC after other treatments haven't worked well enough
  • Can start to work to improve CIC symptoms within hours
  • Helps normalize the number of complete bowel movements per week
  • Taken once a day by mouth

Cons

  • Might cause diarrhea and stomach pain
  • Rare risk of unusual changes in mood or behavior
  • Not safe in people with a gut tear or blockage
  • Unknown if it's safe or works well in children

Common Side Effects for Motegrity

  • Headache (19%)
  • Stomach pain (16%)
  • Nausea (14%)
  • Diarrhea (13%)

Warnings for Motegrity

  • Reports of suicidal thoughts and behavior

Summary for Linzess

Prescription only

Linzess (linaclotide) is used to treat constipation from irritable bowel syndrome (IBS-C) in people 7 years and older. It's also approved for adults with chronic constipation from unknown reasons. In addition, it treats functional constipation in children 2 years and up. This medication belongs to a drug class called guanylate cyclase-C agonists. It helps stool move through the gut more easily. Linzess (linaclotide) comes as a capsule taken by mouth once a day. Diarrhea is a common side effect. Linzess (linaclotide) is brand name only; there's no generic version yet.

Indications for Linzess

Pros and Cons for Linzess

Pros

  • Only need to take once a day
  • Can start to see improvement as early as a week of taking it every day

Cons

  • Must take on an empty stomach (30 minutes before a meal)
  • Can cause diarrhea

Common Side Effects for Linzess

Adults:

  • Diarrhea
  • Stomach pain
  • Having gas
  • Bloating and feeling full in the belly

Children:

  • Diarrhea

Warnings for Linzess

  • Not for children under 2 years old because of risk of serious dehydration
  • Severe diarrhea

Prices with our coupons for Motegrity vs. Linzess

Price Card Drug Icon
Prucalopride30 tablets / 2mg of
$30.81$649.49
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Price Card Drug Icon
Linzess30 capsules / 145mcg
$286.68$385.91
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