Medications for adrenal insufficiency are used to treat Addison's disease, congenital adrenal hyperplasia, and secondary adrenal insufficiency. These medications also have other uses, such as managing inflammation and autoimmune conditions. They work by replacing or supplementing the hormones that your adrenal glands are not producing enough of. Common classes include corticosteroids. Corticosteroids like hydrocortisone (Cortef) are available in oral and injectable forms. Other corticosteroids, such as prednisone and fludrocortisone, are typically taken as oral pills. These medications help maintain your body's balance of hormones and manage symptoms effectively.