Vyepti vs. Emgality for Migraine: Important Differences and Potential Risks.

Vyepti

(eptinezumab)

Emgality

(galcanezumab)

Summary for Vyepti

Prescription only

Vyepti (eptinezumab or eptinezumab-jjmr) is a medication that's used to prevent migraines in adults. The dose is given as an infusion through the veins at a provider's office or clinic every 3 months. Side effects aren't common, but they can include common cold symptoms, itching, and flushing. Vyepti (eptinezumab) is only available as a brand name.

Indications for Vyepti

Prevention of migraines in adults

Pros and Cons for Vyepti

Pros

Works well to lower the number of migraines you get
Taken only every 3 months
Few side effects

Cons

Given as an infusion through the veins (IV)
Needs to be given by a healthcare provider
Hasn't been studied well enough in children or in older adults, so it's not completely known how well the medication works for them

Common Side Effects for Vyepti

Common cold symptoms (6-8%)

Warnings for Vyepti

Allergic reactions

Summary for Emgality

Prescription only

Emgality (galcanezumab or galcanezumab-gnlm) is an injectable medication that can help prevent migraine attacks in adults. It can also help treat cluster headaches in adults. This medication is a monoclonal antibody that works as a CGRP antagonist. It blocks the CGRP protein in the brain that can cause migraine and headache pain. Emgality (galcanezumab) comes as a prefilled pen and syringe. You inject one dose of the medication under the skin monthly. Some common side effects include pain, itching, and redness at the injection site.

Indications for Emgality

Prevention of migraines in adults
Treatment of episodic (occasional) cluster headaches in adults

Pros and Cons for Emgality

Pros

Only needs to be given once a month
Good option for people who have a hard time taking medications by mouth
Generally well tolerated

Cons

Not a good option for people who don't like needles
Need to store in a refrigerator
Not known if the medication works well or is safe in children, during pregnancy, or while breastfeeding