Key takeaways
Trulicity (dulaglutide) and metformin are both medications used to manage Type 2 diabetes in people 10 years and older. However, they belong to different medication classes and have distinct characteristics. Trulicity is a glucagon-like peptide-1 (GLP-1) agonist that is injected once a week, while metformin is a biguanide taken orally, usually two to three times a day. Trulicity is also approved to lower the risk of heart problems in adults with Type 2 diabetes who have heart disease or risk factors, whereas metformin is sometimes used off-label for polycystic ovary syndrome (PCOS). Trulicity does not have a generic version available, while metformin is available in generic form. Common side effects of Trulicity include nausea, vomiting, and diarrhea, and it can increase the risk of low blood sugar when used with insulin. Metformin commonly causes diarrhea and nausea, and it can lead to a serious condition called lactic acidosis, especially when combined with alcohol or certain other medications. Both medications require careful monitoring and consultation with your healthcare team to manage side effects and interactions effectively.
