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Rinvoq vs. Dupixent

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

• Rheumatoid arthritis (RA) in adults
• Psoriatic arthritis (PsA) in adults and children ages 2 years and older
• Eczema (atopic dermatitis) in adults and children ages 12 years and older
• Ulcerative colitis (UC) in adults
• Crohn's disease (CD) in adults
• Ankylosing spondylitis (AS) in adults
• Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
• Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older

• Upper respiratory tract infection (25%)
• Acne (16%)
• Herpes simplex virus (HSV) infection (8%)
• Headache (6%)

Note: Side effects listed were reported by people who took Rinvoq for eczema.

• Serious infections
• Possible higher risk of death for people with rheumatoid arthritis
• Risk of cancer
• Possible risk of heart attack, stroke, and other blood clots
• Severe allergic reaction
• Stomach and gut tears
• Abnormal lab results (e.g., blood cell counts, cholesterol levels)
• Possible harm to unborn babies
• Medication in stool

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

• Moderate-to-severe eczema - for people 6 months and older
• Moderate-to-severe asthma - add-on maintenance for people 6 years and older
• Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
• Eosinophilic esophagitis - for people 1 year and older
• Prurigo nodularis (long-term itchy skin bumps) - for adults
• Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
• Long-term hives - for people 2 years and older
• Bullous pemphigoid (blisters on the skin) - for adults
• Allergic fungal rhinosinusitis (sinus swelling due to fungi) - for people 6 years and older

• Injection site reaction (e.g., pain, swelling, bruising; 10%)
• Eye redness or eye inflammation (10%)
• Cold sores (4%)

• Allergic reactions
• Eye inflammation
• Other inflammation in the body
• Risk of worsening of breathing problems in people with asthma or COPD
• Risk of psoriasis
• Joint pain and psoriatic arthritis
• Unknown effect in people with parasitic worm infections
• Interaction with vaccines