Key takeaways
Nystatin topical and Oravig (miconazole) are both antifungal medications used to treat infections caused by fungi. Nystatin topical is used for fungal skin infections, while Oravig (miconazole) is used for oral thrush in the mouth and throat. Nystatin topical is available in cream, ointment, and powder forms and is applied directly to the skin, whereas Oravig (miconazole) comes as a buccal tablet that dissolves in the mouth. Nystatin topical is available as a lower-cost generic, but Oravig (miconazole) does not have a generic version. Common side effects of nystatin topical include burning and itching at the application site, while Oravig (miconazole) can cause mouth discomfort, diarrhea, and headache. Nystatin topical is safe for all ages, including babies, but Oravig (miconazole) is only recommended for people 16 years and older. Both medications require a prescription and are not available over the counter.
