Key takeaways
Posaconazole (Noxafil) and Fluconazole (Diflucan) are both antifungal medications, but they have some key differences. Posaconazole is used to prevent and treat serious fungal infections caused by *Candida* and *Aspergillus*.It is known for its many drug interactions and potential for liver and kidney damage. On the other hand, Fluconazole is used to treat various *Candida* infections, such as vaginal yeast infections and oral thrush, and can also treat cryptococcal meningitis. Fluconazole is generally well-tolerated. While both medications can cause liver problems, Posaconazole has a higher risk of serious side effects and drug interactions. Additionally, Posaconazole is not recommended for pregnant women due to potential harm to unborn babies, whereas Fluconazole is generally avoided during pregnancy unless necessary. Both medications are available as a lower-cost generic and available in multiple forms, including oral and intravenous.
