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Neurontin vs. Seroquel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Gabapentin (Neurontin) and Quetiapine (Seroquel) are both prescription medications, but they are used for different conditions and belong to different drug classes. Gabapentin is an antiepileptic used to treat certain seizures and nerve pain, while Quetiapine is an atypical antipsychotic used for mood disorders like schizophrenia and bipolar disorder. Gabapentin is typically taken three times a day and is available in generic form, whereas Quetiapine comes in both immediate-release and extended-release forms, with the latter also used to treat depression when combined with another antidepressant. Gabapentin's common side effects include dizziness and sleepiness, while Quetiapine can cause weight gain, high blood sugar, and sleepiness. Additionally, Quetiapine has a higher risk of serious side effects like suicidal thoughts and neuroleptic malignant syndrome, especially in younger people and those with dementia-related psychosis. Gabapentin, on the other hand, can also raise the risk of suicidal thoughts and has potential for misuse, leading some states to classify it as a controlled substance.

Gabapentin

(Neurontin)

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Quetiapine

(Seroquel)

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Summary for Neurontin

Prescription only

Gabapentin, also known by its brand name Neurontin, is used to treat nerve pain from shingles in adults. This medication can also help treat partial (focal) seizures in adults and children. Gabapentin (Neurontin) comes as pills and a liquid that you take by mouth. The dosage depends on things like what you're treating, how old you are, and how well the medication is working. In general, you take it 3 times a day. Common side effects include making you feel dizzy and sleepy.

Indications for Neurontin

Pros and Cons for Neurontin

Pros

  • An option for relieving nerve pain caused by shingles
  • Can take with other anti-seizure medications for partial-onset seizures in people 3 years and older
  • Available as a tablet, capsule, and liquid for those who have trouble swallowing pills

Cons

  • Usually need to taken three times per day
  • Can cause dizziness and sleepiness
  • Can cause withdrawal symptoms if you stop taking the medication too suddenly or too fast

Common Side Effects for Neurontin

  • Sleepiness (19%)
  • Dizziness (17%)
  • Poor muscle control or clumsiness (13%)
  • Fatigue (11%)

Warnings for Neurontin

  • Severe allergic reactions
  • Sleepiness, dizziness, and trouble concentrating
  • Risk of suicidal thoughts and behavior
  • Higher risk of seizures and other side effects if you stop the medication too suddenly or too fast
  • Dangerously slowed breathing
  • Changes in behavior in children

Summary for Seroquel

Prescription only

Quetiapine (Seroquel) is an atypical antipsychotic. It's used to treat mental health problems like schizophrenia and bipolar disorder. This medication comes as an immediate-release tablet (Seroquel) that's taken by mouth usually twice a day. There's also an extended-release tablet (Seroquel XR) that's taken once a day. The specific dosage depends on how well it's helping your mood, thoughts, and behaviors. Side effects can include sleepiness, headache, and possible weight gain. There are brand-name and generic versions of this medication.

Indications for Seroquel

Pros and Cons for Seroquel

Pros

  • Taken by mouth
  • Might notice an improvement in your symptoms in as early as a week of starting the medication
  • Available in both short-acting and long-acting tablets

Cons

  • Might cause weight gain
  • Can raise your blood sugar and cholesterol levels
  • Not recommended for older adults who have dementia-related psychosis

Common Side Effects for Seroquel

Immediate-release tablets:

  • Headache (21%)
  • Agitation (20%)
  • Sleepiness (18%)
  • Dizziness (11%)
  • Dry mouth (9%)
  • Constipation (8%)
  • Pain (7%)
  • Fast heart rate (6%)
  • Vomiting (6%)

Extended-release tablets:

Warnings for Seroquel

  • Higher risk of death and stroke in older people with dementia-related psychosis
  • Risk of suicidal thoughts and behavior
  • Neuroleptic malignant syndrome
  • High blood sugar, high cholesterol, and weight gain
  • Trouble controlling muscle movements (tardive dyskinesia)
  • Changes in blood pressure
  • Risk of falls
  • Risk of infection (due to low white blood cell counts)
  • Possible changes in heart rhythm
  • Seizures
  • Hypothyroidism (low thyroid hormone)
  • High prolactin levels
  • Feeling very sleepy and having trouble concentrating

Prices with our coupons for Neurontin vs. Seroquel

Price Card Drug Icon
Gabapentin60 capsules / 300mg
$10.29$111.23
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Quetiapine30 tablets / 25mg
$9.00$9.00
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