Key takeaways
Gabapentin (Neurontin) and venlafaxine (Effexor XR) are both prescription medications that can treat nerve pain caused by diabetes (diabetic neuropathy). But they belong to different drug classes and are approved for different conditions in addition to nerve pain. Gabapentin is an antiseizure medication that also treats certain types of seizures and nerve pain caused by shinges. It isn't FDA-approved to treat diabetic neuropathy, so this is considered an off-label use. Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) that also treats depression, anxiety, and other mood-related health conditions. Both medications come in immediate-release and extended-release dosage forms. Gabapentin side effects include dizziness and drowsiness. It also has a risk of dependence and misuse, so some states classify gabapentin as a controlled substance. Venlafaxine side effects include nausea, constipation, and sweating. Both medications carry an increased risk of suicidal throughts or behaviors for people age 24 years or younger. Additionally, both medications can cause withdrawal symptoms if stopped abruptly, so it's important to follow your prescriber's instructions when discontinuing them.
