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Kerendia vs. Spironolactone

Kerendia (finerenone) is a mineralocorticoid receptor antagonist used to lower the risk of serious kidney and heart problems. It's approved for adults with chronic kidney disease (CKD) caused by Type 2 diabetes and for certain adults with heart failure. You take the medication by mouth once a day, with or without food. Common side effects include high potassium levels, low blood pressure, and low sodium levels.

• Lowers the risk of serious problems in adults with chronic kidney disease (CKD) caused by Type 2 diabetes
• Lowers the risk of serious problems in certain adults with heart failure

• High blood potassium levels (14%)

• High potassium levels
• Worsening kidney function (people with heart failure)

Spironolactone (Aldactone) is a type of potassium-sparing diuretic (water pill). It's used to treat heart failure, high blood pressure, and swelling from kidney or liver problems in adults. Because it blocks aldosterone (a hormone that affects sodium and potassium levels), spironolactone (Aldactone) can also treat conditions where there's too much aldosterone. Spironolactone (Aldactone) is taken by mouth, generally once or a few times a day, depending on your condition. Some common side effects of this medication include breast tenderness (males and females) and loss of libido (in males).

• Heart failure
• High blood pressure
• Swelling due to liver damage (cirrhosis)
• Swelling due to nephrotic syndrome (a rare kidney condition) - tablets only
• Primary aldosteronism (a hormone imbalance) - tablets only

• Dizziness
• Headache
• Sleepiness
• Nausea
• Vomiting
• Diarrhea
• Stomach cramps
• Enlargement of male breasts
• Breast pain
• Lower sex drive
• Sexual dysfunction
• Irregular or lack of menstrual periods
• Leg cramps
• Higher potassium levels
• Lower sodium levels

• High blood potassium levels
• Low blood pressure and kidney problems
• Abnormal electrolyte levels
• Breast pain or swelling