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Jardiance vs. Ozempic

Jardiance (empagliflozin) is a medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

• Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
• Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
• Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
• Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

• Urinary tract infection (UTI; 8-9%)
• Vaginal yeast infection in females (5-6%)
• Upper respiratory tract infection (3-4%)
• High cholesterol or fat levels (3-4%)
• Urinating more than usual (3%)

• Ketoacidosis
• Low fluids in the body (leading to low blood pressure or dehydration)
• Genital and urinary tract infections
• Low blood sugar (hypoglycemia) when used with certain other diabetes medications
• Leg and foot amputations
• Allergic reactions

Ozempic (semaglutide) is a GLP-1 agonist used with diet and exercise to help adults manage Type 2 diabetes. It can also lower the risk of heart attack, stroke, and heart-related death in some people with Type 2 diabetes. It comes as a once-weekly injection under the skin and as a tablet taken by mouth once a day. The injection is also approved to help slow worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Common side effects include nausea, vomiting, and diarrhea.

Injection:

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes and heart disease
• Lower the risk of worsening kidney problems and heart-related death in adults with Type 2 diabetes and chronic kidney disease (CKD)

Tablets:

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes at high risk for these events

• Nausea (16-20%)
• Diarrhea (9%)
• Vomiting (5-9%)
• Stomach pain (6-7%)
• Constipation (3-5%)

Note: Side effects listed above are for Ozempic (semaglutide) injection

• Risk of thyroid tumors
• Inflammation of the pancreas (pancreatitis)
• Eye problems
• Low blood sugar (hypoglycemia) when taken with certain diabetes medications
• Kidney damage
• Severe stomach problems
• Severe allergic reactions
• Gallbladder problems
• Lung problems during anesthesia or deep sedation