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Jardiance vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Jardiance (empagliflozin) and Mounjaro (tirzepatide) are both medications used to treat Type 2 diabetes, but they belong to different drug classes and have distinct characteristics. Jardiance is a sodium-glucose cotransporter 2 (SGLT2) inhibitor taken orally once a day, while Mounjaro is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist injected subcutaneously (under the skin) once weekly. Jardiance is also approved to lower the risk of heart and kidney complications in certain adults, whereas Mounjaro is not. Both are only available as brand-name medications. Common side effects of Jardiance include urinary tract infections and yeast infections, while Mounjaro often causes nausea, vomiting, and diarrhea. Both medications can cause low blood sugar when used with other diabetes treatments, but Mounjaro also carries a risk of thyroid cancer and pancreatitis. Additionally, Jardiance may lead to dehydration and low blood pressure, while Mounjaro can cause stomach and gallbladder issues.

Jardiance

(empagliflozin)

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Mounjaro

(tirzepatide)

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Summary for Jardiance

Prescription only

Jardiance (empagliflozin) is a medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

Indications for Jardiance

  • Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
  • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
  • Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
  • Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

Pros and Cons for Jardiance

Pros

  • Taken by mouth once a day
  • Unlikely to cause weight gain
  • Can take with other diabetes medications

Cons

Common Side Effects for Jardiance

Warnings for Jardiance

  • Ketoacidosis
  • Low fluids in the body (leading to low blood pressure or dehydration)
  • Genital and urinary tract infections
  • Low blood sugar (hypoglycemia) when used with certain other diabetes medications
  • Leg and foot amputations
  • Allergic reactions

Summary for Mounjaro

Prescription only

Mounjaro (tirzepatide) is a prescription injection used to improve blood sugar control in people 10 years and older with Type 2 diabetes. It works best when you also follow a nutritious diet and exercise regularly. Mounjaro (tirzepatide) belongs to the drug class called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea and diarrhea. It can also lower your appetite, which might lead to some weight loss.

Indications for Mounjaro

Pros and Cons for Mounjaro

Pros

  • Given once weekly
  • Can lower A1C by an average of up to 2.3% in about 9 months
  • Has different forms some people can choose from (vials, single-dose injectable pens, multi-dose KwikPens)
  • Can use if you have liver or kidney problems

Cons

  • Must give as an injection given under the skin
  • Can cause unpleasant side effects like nausea, vomiting, and diarrhea
  • Takes time to reach a dose that works well
  • Might not be safe during pregnancy

Common Side Effects for Mounjaro

  • Nausea (12-18%)
  • Diarrhea (12-17%)
  • Low appetite (5-11%)
  • Vomiting (5-9%)
  • Indigestion (5-8%)
  • Constipation (6-7%)
  • Stomach pain (5-6%)

Warnings for Mounjaro

  • Risk of thyroid cancer
  • Inflammation of the pancreas (pancreatitis)
  • Low blood sugar (hypoglycemia) when used with other diabetes medications
  • Allergic reactions
  • Stomach side effects
  • Kidney damage due to dehydration
  • Eye problems in people with diabetic retinopathy
  • Gallbladder problems
  • Lung problems during general anesthesia or deep sedation
  • Don't share Mounjaro KwikPens with anyone

Prices with our coupons for Jardiance vs. Mounjaro

Price Card Drug Icon
Jardiance30 tablets / 10mg
$354.86$430.65
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Price Card Drug Icon
Mounjaro1 carton / 4 pens of 2.5mg/0.5ml
$1,056.63$1,335.00
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