Key takeaways
Sumatriptan (Imitrex) and divalproex (Depakote) are both prescription medications, but they serve different purposes and belong to different drug classes. Sumatriptan is a triptan used to treat migraines in adults, while divalproex is an antiepileptic used to treat seizures, prevent migraines, and manage bipolar disorder. Sumatriptan works by tightening blood vessels in the brain and reducing inflammation, whereas divalproex increases the levels of GABA, a calming chemical in the brain, to control seizures. Sumatriptan is taken as needed for migraines, but divalproex is taken daily, either once or twice, depending on the formulation. Sumatriptan can cause side effects like tingling and fatigue, while divalproex can lead to nausea, sleepiness, and weight changes. Additionally, divalproex requires regular blood tests to monitor liver health, and it is not safe to use during pregnancy. Both medications have generic versions available, making them more affordable.
