Key takeaways
Ibsrela (tenapanor) and Amitiza (lubiprostone) are both used to treat constipation, but they work in different ways and are used for different types of constipation. Ibsrela is specifically for irritable bowel syndrome with constipation (IBS-C) in adults and works by preventing sodium absorption in the gut, which increases water in the intestines to soften stool. Additionally, it works on the nerves in the gut to help relieve stomach pain. Amitiza, on the other hand, is a chloride channel activator that increases chloride and fluid in the intestines, making it easier for stool to pass. Amitiza is used for long-term constipation of unclear cause, opioid-induced constipation, and IBS-C in women 18 years or older. Ibsrela is taken twice daily before meals, while Amitiza is also taken twice daily with food and water to prevent nausea. Both medications can cause diarrhea, while other side effects of Ibsrela include bloating and gas, whereas Amitiza can cause nausea and low blood pressure. Amitiza is available in a generic form, which might be more affordable, while Ibsrela is only available as a brand-name medication.
