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Activella vs. Provera

Activella is a combination hormone replacement therapy (HRT) that contains estradiol (an estrogen) and norethindrone (a progestin). It's used to treat certain symptoms of menopause, such as night sweats and vaginal dryness, related to low estrogen levels. It can also help prevent bone loss (osteoporosis) in females who've reached menopause. The typical dose is 1 tablet by mouth once daily. Some side effects of this medication include breast pain and headache. Activella (estradiol / norethindrone), as well as other HRTs, isn't recommended for people who've had breast cancer.

Activella is a brand-name medication. It also comes as a generic and branded generics, such as Mimvey.

In females who have a healthy uterus:

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe symptoms of vulvar and vaginal atrophy, like vaginal dryness
• Prevention of osteoporosis in females who've reached menopause

• Breast pain (17-24%)
• Headache (11-17%)
• Accidental injury (3-17%)
• Upper respiratory tract infection, like cough, cold, sore throat, congestion (10-15%)
• Sinus infection (7-15%)
• Postmenopausal bleeding (10-11%)
• Nausea (10-11%)
• Weight gain (up to 9%)
• Ovarian cyst (up to 7%)
• Stomach flu (up to 6%)
• Viral infection (up to 6%)
• Vaginal yeast infection (up to 6%)
• Mood swings (up to 6%)
• Back pain (3-6%)

• Blood clots, heart attacks, and strokes
• Breast cancer
• Uterine or endometrial cancer
• Dementia
• Ovarian cancer
• Liver or gallbladder problems
• Changes in calcium levels in the blood
• Vision problems
• High triglyceride (fat) levels
• Low thyroid hormone levels
• Buildup of fluids in your body (fluid retention)
• Worsening of other medical conditions

Medroxyprogesterone (Provera) can help make your menstrual cycles more regular. It also helps protect the uterus from harm in people who've gone through menopause and are taking estrogen replacement medications. When taken with estrogen therapy, it has some serious risks that you should consider if you need treatment for a long time.

• Lack of menstrual periods due to hormone imbalance
• Irregular periods due to hormone imbalance
• Protection of the uterus in postmenopausal women who are taking estrogen medications

• Spotting or breakthrough bleeding
• Heavier or lighter periods
• Breast tenderness
• Nausea

• When taken with estrogen medications:
• Blood clots and their complications (heart attack, stroke)
• Breast cancer
• Dementia
• Uterine and ovarian cancer
• Vision problems
• Higher blood pressure and cholesterol levels
• Swelling (fluid buildup)