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Mimvey Coupon - Mimvey 28 tablets of 1mg/0.5mg package

estradiol / norethindrone

Generic Mimvey
Used for Osteoporosis, Menopause
Used for Osteoporosis, Menopause

Mimvey is a combination hormone replacement therapy (HRT) that contains estradiol (an estrogen) and norethindrone (a progestin). It's used to treat certain symptoms of menopause, such as night sweats and vaginal dryness, related to low estrogen levels. It can also help prevent bone loss (osteoporosis) in females who've reached menopause. The typical dose is 1 tablet by mouth once daily. Some side effects of this medication include breast pain and headache. Mimvey (estradiol / norethindrone), as well as other HRTs, isn't recommended for people who've had breast cancer.

Mimvey is a branded generic of Activella, the brand name medication. Other generics that are like Mimvey include estradiol/norethindrone.

Last reviewed on September 12, 2024
basics-icon

What is Mimvey (estradiol / norethindrone)?

What is Mimvey (estradiol / norethindrone) used for?

In females who have a healthy uterus:

How Mimvey (estradiol / norethindrone) works

Your ovaries make estrogen and progesterone, which are important hormones that help control your menstrual cycles. As the body ages and goes through menopause, your ovaries make less and less of these hormones. This can lead to certain symptoms, including hot flashes and night sweats.

Mimvey (estradiol / norethindrone) is hormone replacement therapy (HRT) that replaces estrogen and progesterone hormones during menopause:

Are you looking for information on Activella (estradiol / norethindrone) instead?

Drug Facts

Common BrandsMimvey
Drug ClassEstrogen replacement / Progestin
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$376.77(save 85.09%)
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$56.17
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What are the side effects of Mimvey (estradiol / norethindrone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Breast pain (17-24%)
  • Headache (11-17%)
  • Accidental injury (3-17%)
  • Upper respiratory tract infection, like cough, cold, sore throat, congestion (10-15%)
  • Sinus infection (7-15%)
  • Postmenopausal bleeding (10-11%)
  • Nausea (10-11%)
  • Weight gain (up to 9%)
  • Ovarian cyst (up to 7%)
  • Stomach flu (up to 6%)
  • Viral infection (up to 6%)
  • Vaginal yeast infection (up to 6%)
  • Mood swings (up to 6%)
  • Back pain (3-6%)

Other Side Effects

  • Changes in vaginal bleeding pattern (e.g., breakthrough bleeding, spotting, lack of periods)
  • Stomach pain
  • Gas
  • Bloating
  • Diarrhea
  • Common cold
  • Trouble sleeping
  • Fatigue (tiredness)
  • Dizziness
  • Nervousness
  • Hair loss or excessive hair growth
  • Swelling of the arms, legs, or feet
  • Changes in weight
  • Changes in appetite
  • Changes in sex drive

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Blood clots: trouble breathing, leg pain or swelling, skin that's warm to the touch
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweats, lightheadedness
  • Stroke: sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache
  • High calcium levels: tiredness, muscle weakness, nausea, vomiting, constipation
  • Low calcium levels: muscle spasms or twitching, numbness and tingling in your fingers, toes, or around your mouth
  • Unusual vaginal bleeding, vaginal discharge, or pelvic pain
When do Mimvey (estradiol / norethindrone) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Postmenopausal bleeding
Breast pain
Headache

Source: DailyMed

The following side effects have also been reported

Women rarely have severe side effects from taking estrogens to replace estrogen. Discuss these possible effects with your doctor:

The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than 1 year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer, and no need to take an estrogen and progestin combination.

It is not yet known whether the use of estrogens increases the risk of breast cancer in women. Although some large studies show an increased risk, most studies and information gathered to date do not support this idea.

Check with your doctor immediately if any of the following side effects occur:

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Breast pain or tenderness

dizziness or light-headedness

headache

rapid weight gain

swelling of feet and lower legs

vaginal bleeding

Rare

Breast lumps

change in vaginal discharge

discharge from nipple

nausea and vomiting

pains in chest, groin, or leg, especially calf

pains in stomach, side, or abdomen

pain or feeling of pressure in pelvis

severe or sudden headache

sudden and unexplained shortness of breath

sudden loss of coordination

sudden slurred speech

sudden vision changes

weakness or numbness in arm or leg

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

bloating or gas

dizziness

general feeling of tiredness

flu-like symptoms

mental depression

muscle aches

nausea—taking tablet with food may decrease

vaginitis

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Mimvey (estradiol / norethindrone)

thumbs-up

Pros

Taken by mouth once daily

Includes a progestin to protect against endometrial cancer

Available as a lower-cost generic medication

thumbs-down

Cons

Raises your risk of blood clots, heart attack, and stroke

Not for people who've had breast cancer

Not a first-choice option for vaginal symptoms of menopause or for preventing osteoporosis

pharmacist-tips

Pharmacist tips for Mimvey (estradiol / norethindrone)

pharmacist
  • Take Mimvey (estradiol / norethindrone) once a day at the same time every day. You can use the calendar on the package to mark and keep track of your doses.

    • Mimvey (estradiol / norethindrone) can cause irregular vaginal bleeding, including breakthrough bleeding and spotting. This side effect is more likely to happen when you first start treatment and should get better over time. If you notice irregular vaginal bleeding, talk with your healthcare team. While this is an expected side effect, there's a rare chance that spotting or irregular bleeding might be a symptom of cervical cancer.

      • Taking an estrogen-containing medication, like Mimvey (estradiol / norethindrone), might lead to higher blood sugar levels or higher blood pressure. If you already have diabetes or high blood pressure, your healthcare team might ask you to check your blood pressure or blood sugar levels more often while you're taking Mimvey (estradiol / norethindrone).

        • Taking Mimvey (estradiol / norethindrone) might raise your risk for certain types of cancers, such as breast cancer and uterine cancer. Your healthcare team might ask you to have a pelvic exam, breast exam, and mammogram once a year while you're taking this medication. Ask your healthcare team if you're not sure how to schedule these screenings.

          • Since Mimvey (estradiol / norethindrone) can cause many bothersome side effects and serious risks, your healthcare team will likely recommend that you take the medication for the shortest period of time possible to treat your symptoms. Make sure to check in with your prescriber regularly to discuss if you still need to take Mimvey (estradiol / norethindrone).

            faqs

            Frequently asked questions about Mimvey (estradiol / norethindrone)

            Does Mimvey (estradiol / norethindrone) have estrogen?
            Yes, Mimvey (estradiol / norethindrone) contains estradiol, an estrogen replacement. Estradiol relieves symptoms of menopause caused by low estrogen levels, such as hot flashes, night sweats, and vaginal dryness or irritation. It can also help prevent bone loss and improve bone health.
            Is Mimvey (estradiol / norethindrone) birth control?
            No, Mimvey (estradiol / norethindrone) isn't a birth control. It's a hormone replacement therapy (HRT) used to relieve certain menopausal symptoms and to prevent osteoporosis in females who've gone through menopause. But there are combined oral contraceptives (COC) that contain estrogen and progestin combinations similar to those in Mimvey (estradiol / norethindrone). For example, many COCs contain ethinyl estradiol and norethindrone, such as Junel 1.5/30.
            Does Mimvey (estradiol / norethindrone) cause weight gain?
            Though not common, some people who took Mimvey (estradiol / norethindrone) in clinical studies did report weight gain. But the cause of their weight gain wasn't clear. Other studies showed that taking a HRT isn't likely to cause weight gain from an increase in body fat, but it might lead to some bloating from fluids. In general, people are more likely to experience weight gain as a result of the changes their bodies go through during menopause, than as a side effect from an HRT. If you're concerned about weight gain, while taking Mimvey (estradiol / norethindrone), talk with your healthcare team.
            Does Mimvey (estradiol / norethindrone) cause hair loss?
            There have been reports of people who experienced hair loss on their scalp after starting Mimvey (estradiol / norethindrone). But it's unclear if the hair loss was caused by Mimvey (estradiol / norethindrone) or a result of menopause. In general people who undergo menopause can experience hair thinning and slower hair growth because of hormone changes in their body. Talk with your healthcare professional if you have concerns about hair loss in menopause.
            How quickly does Mimvey (estradiol / norethindrone) work?
            How quickly Mimvey (estradiol / norethindrone) works can differ from person to person, depending on what medical condition they're taking this medication for. For example, many people who took Mimvey (estradiol / norethindrone) for hot flashes reported a noticeable decline in the number and severity of hot flashes by week 4 of treatment. Talk with your healthcare team about what results you might expect after starting Mimvey (estradiol / norethindrone).
            When is the best time to take Mimvey (estradiol / norethindrone)?
            Take Mimvey (estradiol / norethindrone) once a day at the same time every day. The best time to take this medication is a time when you can remember to take it consistently daily. Mimvey (estradiol / norethindrone) can be taken with or without food. But if this medication makes you feel nauseous, taking it with food might help.
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            What are the risks and warnings for Mimvey (estradiol / norethindrone)?

            Mimvey (estradiol / norethindrone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Blood clots, heart attacks, and strokes

            • Risk factors: Personal or family history of blood clots | High blood pressure | Diabetes (high blood sugar) | High cholesterol | Tobacco use | Obesity | Systemic lupus erythematosus (SLE)

              Estrogen/progestin oral HRTs, such as Mimvey (estradiol / norethindrone), and estrogen-only HRTs can raise your risk of blood clots. These blood clots can travel anywhere in your body and block blood flow, including your legs or arms (deep vein thrombosis, DVT) and your lungs (pulmonary embolism, PE). They can also travel to your heart, which can lead to a heart attack, or your brain, which can lead to a stroke. You're at higher risk of blood clots if you or anyone in your family has had them in the past, if you smoke tobacco, or if you have certain conditions, like high blood pressure and high cholesterol.

              Let your healthcare professional (HCP) know you're using Mimvey (estradiol / norethindrone). Because of the risk of developing blood clots, you will need to stop using Mimvey (estradiol / norethindrone) before certain types of surgeries or periods of time when you won't be moving much. Your HCP will let you know how long before the surgery you need to stop using Mimvey (estradiol / norethindrone). To lower your risk of blood clots, wear compression leggings or get up and stretch often on long car or plane trips.

              Let your HCP know if you have pain or swelling in your legs or arms, as this can be a symptom of a blood clot. Call 911 and get medical help right away if you have trouble breathing, chest or arm pain, facial drooping, weakness on one side of the body, severe headaches, or sudden changes in your speech or vision, since these can be signs of life-threatening complications of blood clots.

              risk-warning

              Breast cancer

              • Risk factors: Personal or family history of breast cancer | Using hormonal therapy for a long period of time

                Estrogen/progestin combination HRTs, like Mimvey (estradiol / norethindrone), can raise your risk of breast cancer. This risk might be higher compared to estrogen-only therapy. Don't use Mimvey (estradiol / norethindrone) if you currently have or have had breast cancer in the past. You're also at greater risk if you've used Mimvey (estradiol / norethindrone) or similar medications for a long period of time. To lower your risk of breast cancer, your HCP will prescribe the lowest dose of estrogen for the shortest period of time possible. It's important that you regularly check your breasts for any changes and get breast scans (mammograms) done. Let your healthcare professional know if you notice any unusual changes in breast shape, size, or color.

                risk-warning

                Uterine or endometrial cancer

                • Risk factors: Estrogen therapy without additional progestin | People with a healthy uterus | Using estrogen therapy for more than 1 year | High estrogen dose

                  Mimvey (estradiol / norethindrone) contains estradiol, which works like estrogen in your uterus. It can change the lining of your uterus, called the endometrium. Uncontrolled growth of the uterus lining can cause uterine or endometrial cancer in people with a healthy uterus. This risk is especially high in people taking estrogen therapy without a progestin to balance out estrogen's effect on the growth of the uterine lining. You can still have the risk of uterine cancer several years after stopping your hormonal therapy.

                  People using Mimvey (estradiol / norethindrone) might have a lower risk of uncontrolled endometrial growth compared to those taking estrogen-only therapy, since Mimvey (estradiol / norethindrone) contains a progestin. Regardless of the hormonal therapy you're taking, it's important to be aware of the warning signs of uterine (endometrial) cancer, including vaginal bleeding that doesn't go away or keeps coming back. Let your HCP know if you notice any unusual vaginal bleeding. If you're worried about getting uterine cancer, talk to your HCP.

                  risk-warning

                  Dementia

                  • Risk factors: Age 65 years or older

                    People taking estrogen/progestin combinations or estrogen-only therapy might be at greater risk for dementia. Your risk is higher if you start hormonal therapy after age 65. Estrogen/progestin combination and estrogen-only therapies shouldn't be used to prevent dementia. Early symptoms of dementia include new forgetfulness, confusion, getting lost, and wandering out into the neighborhood. If the risk of dementia worries you, talk to your HCP.

                    risk-warning

                    Ovarian cancer

                    Estrogen/progestin combinations and estrogen-only therapy can potentially raise the risk of ovarian cancer in females using HRTs. If you notice any unusual vaginal bleeding, vaginal discharge, or pelvic pain, talk to your healthcare professional (HCP). These can be signs of ovarian cancer.

                    risk-warning

                    Liver or gallbladder problems

                    • Risk factors: History of liver disease or jaundice

                      Estrogen therapy can raise the risk of gallbladder disease. Let your HCP know if you've had jaundice (yellowing of your skin or eyes, or dark urine) in the past. If your jaundice comes back while using Mimvey (estradiol / norethindrone), stop the medication and talk to your HCP. These can be signs of liver damage or gallbladder disease.

                      risk-warning

                      Changes in calcium levels in the blood

                      • Risk factors: Breast cancer | Cancer that has spread to the bones | Low parathyroid hormone levels

                        Estrogen therapy can change the calcium levels in your blood. Females with breast cancer that has spread to the bones are at higher risk of extremely high calcium levels. Symptoms of high calcium levels include feeling tired and having muscle weakness, nausea, vomiting, or constipation.

                        On the other hand, females with low parathyroid hormone levels from the parathyroid gland are at higher risk of low calcium levels during estrogen therapy. Symptoms of low calcium levels include muscle spasms or twitching and numbness and tingling in your fingers, toes, or around your mouth.

                        Let your HCP know if you notice any of these symptoms. You might need regular blood tests done so that your HCP can check your calcium levels while you're taking Mimvey (estradiol / norethindrone).

                        risk-warning

                        Vision problems

                        Although very rare, some people taking estrogens have had vision problems due to clot formation in the eyes. If you have sudden partial or complete vision loss, bulging eyes, double vision, or migraines, stop Mimvey (estradiol / norethindrone) and tell your HCP.

                        risk-warning

                        High triglyceride (fat) levels

                        • Risk factors: History of high triglyceride levels in the blood

                          Estrogen therapy might raise the triglyceride (fat) levels in your blood. Too much triglyceride in your blood can lead to problems in your pancreas, including swelling (pancreatitis). You might need to get blood tests done regularly while taking Mimvey (estradiol / norethindrone) so your HCP can make sure your pancreas is healthy. If you experience signs of pancreatitis, like stomach pain that spreads to your back, stomach tenderness, fever, nausea, or vomiting, let your HCP know right away.

                          risk-warning

                          Low thyroid hormone levels

                          • Risk factors: Conditions that cause low thyroid hormone levels

                            Estrogens can cause changes in the thyroid hormone levels in your body. If you have conditions that cause low thyroid hormone levels, your body can't adjust these levels to keep them in the normal range. If you're taking thyroid replacement medication for your thyroid condition, you might need to take a higher dose. You also might need to get regular blood tests done while using Mimvey (estradiol / norethindrone) to make sure your thyroid hormone levels are normal.

                            risk-warning

                            Buildup of fluids in your body (fluid retention)

                            • Risk factors: Certain heart conditions | Kidney damage

                              Estrogen/progestin combination therapies can cause excess fluids to build up inside your body. Signs of fluid retention include swelling of your hands and ankles. You're at higher risk of fluid retention if you have certain heart conditions, like heart failure, or kidney damage. If you have these conditions, let your HCP know if you notice any signs of worsening fluid retention while using Mimvey (estradiol / norethindrone).

                              risk-warning

                              Worsening of other medical conditions

                              Taking estrogen-containing medications can worsen certain medical conditions. These include high blood pressure, hereditary angioedema, asthma, diabetes, migraine, and seizures. Before you start Mimvey (estradiol / norethindrone) let your healthcare team know about your past medical history so they can talk with you about the risks and benefits of taking this medication.

                              dosage

                              Mimvey (estradiol / norethindrone) dosage forms

                              The average cost for 3 packages of 28 tablets of 1mg/0.5mg of Mimvey (estradiol / norethindrone) is $56.17 with a free GoodRx coupon. This is 85.09% off the average retail price of $376.77.
                              package
                              Package
                              DosageQuantityPrice as low asPrice per unit
                              28 tablets of 1mg/0.5mg3 packages$56.17$18.72

                              Typical dosing for Mimvey (estradiol / norethindrone)

                              Each Mimvey tablet contains 1 mg of estradiol and 0.5 mg of norethindrone.

                              • Adults: The typical dose is 1 tablet by mouth once daily.

                              interactions

                              Interactions between Mimvey (estradiol / norethindrone) and other drugs

                              Mimvey (estradiol / norethindrone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Mimvey (estradiol / norethindrone). Please note that only the generic name of each medication is listed below.

                              Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

                              Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

                              Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                              drug-cost

                              How much does Mimvey (estradiol / norethindrone) cost?

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                              contraindications-icon

                              Mimvey (estradiol / norethindrone) contraindications

                              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Mimvey (estradiol / norethindrone) will not be safe for you to take.
                              • Undiagnosed abnormal vaginal bleeding

                              • History of breast cancer

                              • History of other estrogen-sensitive cancer or tumor

                              • History of blood clots traveling to your extremities (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE)

                              • History of heart attack or stroke

                              • Liver disease

                              • Blood clotting conditions

                              alternatives

                              What are alternatives to Mimvey (estradiol / norethindrone)?

                              There are a number of medications that your doctor can prescribe in place of Mimvey (estradiol / norethindrone). Compare a few possible alternatives below.
                              Mimvey (estradiol / norethindrone)
                              Used for:

                              In females who have a healthy uterus:

                              $56.17 Lowest GoodRx priceView Prices
                              Used for:
                              • Moderate-to-severe vasomotor symptoms of menopause, such as hot flashes and night sweats

                              • Moderate-to-severe vaginal dryness, burning, and irritation caused by menopause

                              $870.00 Lowest GoodRx priceView Prices
                              Used for:
                              $42.08 Lowest GoodRx priceView Prices
                              images

                              Mimvey (estradiol / norethindrone) images

                              White Round 34 And B - Mimvey 1mg-0.5mg Tablet
                              This medicine is White, Round Package Imprinted With "B" And "34".White Round 34 And B - Mimvey 1mg-0.5mg Tablet

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                              References

                              Best studies we found
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