How Much Is Progesterone Without Insurance?
How much progesterone costs without insurance depends on several factors, including what form you’re prescribed. Learn more with GoodRx.
progesterone injection
Used for Endometriosis, Fertility, Irregular Menstruation
Used for Endometriosis, Fertility, Irregular Menstruation
Progesterone injection is a progestin hormone used to treat missed menstrual periods and abnormal uterine bleeding caused by hormone imbalances. It comes as an oil-based injection that's typically injected into the muscle once a day for several days. Side effects include injection-site pain, weight changes, and breast tenderness. It can also cause symptoms of an allergic reaction in people who are allergic to sesame oil or seeds.
What is Progesterone injection?
What is Progesterone injection used for?
- Missed menstrual periods caused by a hormone imbalance
- Abnormal bleeding from the uterus caused by a hormone imbalance
How Progesterone injection works
Progesterone injection is a progestin that works like progesterone, a hormone your body naturally makes that helps control the menstrual cycle. When your body doesn’t make enough progesterone, replacing it can help trigger a menstrual period and control abnormal bleeding caused by a hormone imbalance.
When does Progesterone injection start working?Time passed since treatment started:
Drug facts
| Common Brands | No brand names available |
|---|---|
| Drug Class | Progestin |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Progesterone injection
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Injection site reactions
- Breakthrough bleeding
- Changes in menstrual flow
- Weight changes
- Swelling
- Vaginal discharge
- Breast tenderness
Less Common Side Effects
- Acne
- Depression
- Hair loss or hair growth
- Trouble sleeping
- Sleepiness
- Nausea
Progesterone injection serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: trouble breathing, hives, rash, itchiness, swelling of your face, lips, tongue, or throat
- Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw, sweating, trouble breathing
- Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face, severe headache
- Blood clot in the lungs: shortness of breath, chest pain, cough
- Blood clot in the eyes: sudden vision loss, blurry vision, changes in vision, migraine
- Pneumonia: fever, trouble breathing, fatigue, night sweats, cough
- Liver problems: nausea, yellowing of the skin or whites of the eyes, stomach pain
- Breast lumps: breast pain or soreness, swelling, rash
- Unusual vaginal bleeding: abnormal spotting or bleeding
The following Progesterone injection side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Clear or bloody discharge from the nipple
dimpling of the breast skin
inverted nipple
lump in the breast or under the arm
persistent crusting or scaling of the nipple
redness or swelling of the breast
sore on the skin of the breast that does not heal
Incidence not known
Abdominal or stomach pain
blurred vision
change in vaginal discharge
clay-colored stools
cleft lip or palate
confusion
darkened urine
difficult or labored breathing
difficulty with swallowing
difficulty with walking
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fainting
fast, pounding, or irregular heartbeat or pulse
headache
indigestion
irregular heartbeat
irritation
joint pain, stiffness, or swelling
lightheadedness
loss of appetite
nervousness
noisy breathing
numbness or tingling in the face, arms, or legs
pain or feeling of pressure in the pelvis
pains in the stomach, side, or abdomen, possibly radiating to the back
pounding in the ears
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
redness of the skin
shortness of breath
slow heartbeat
spontaneous abortion
stomach or pelvic discomfort, aching, or heaviness
sweating
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
trouble speaking, thinking, or walking
unpleasant breath odor
unusual tiredness or weakness
vaginal bleeding
vomiting
vomiting of blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Attack, assault, or force
blurred or loss of vision
change in walking and balance
changes in behavior
changes in patterns and rhythms of speech
choking
clumsiness or unsteadiness
confusion about identity, place, and time
continuing ringing or buzzing or other unexplained noise in the ears
decreased awareness or responsiveness
difficulty with moving
disturbed color perception
double vision
drowsiness
extreme dizziness or drowsiness
feeling drunk
feeling of constant movement of self or surroundings
feeling of unreality
hair loss or thinning of the hair
halos around lights
hearing loss
hives or welts
longer or heavier menstrual periods
loss of consciousness
muscle cramps
muscle stiffness
night blindness
normal menstrual bleeding occurring earlier, possibly lasting longer than expected
overbright appearance of lights
redness of the skin
relaxed and calm
sensation of spinning
sense of detachment from self or body
severe sleepiness
sleepiness
slurred speech
swollen tongue
thoughts of killing oneself
tunnel vision
weight changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Progesterone injection
Pros
- Helps to regulate your menstrual period
- Only has to be taken once a day
- Treatment courses are usually short
Cons
- Requires an injection into a muscle
- Not a good option if you're allergic to sesame oil
- Has a risk of serious blood clots
Pharmacist tips for Progesterone injection
- Use progesterone injection for the full number of days that you're prescribed. The treatment schedule is different depending on what you're using it for.
- If you're using progesterone injection because you don't get periods, you can expect a withdrawal bleed (like a period) around 2 to 3 days after your last injection. Your body might have normal menstrual cycles after this. Tell your prescriber if you don't have any bleeding within a few days after using this medication for 8 days in a row.
- Progesterone injection can make you feel tired or dizzy. Don't drive or perform dangerous activities without seeing how it affects you first.
- If you're using progesterone injection for missed periods, bleeding similar to a period usually starts about 2 to 3 days after your last injection. Tell your prescriber if you don't have any bleeding after finishing treatment.
- Progesterone injection can make you feel tired or dizzy. Don't drive or do dangerous activities until you know how the medication affects you.
- Tell your prescriber if you have unusual or heavy vaginal bleeding, a breast lump, vision changes, or severe headaches while using progesterone injection. These could be signs of a more serious problem.
- Get medical help right away if progesterone injection causes sudden shortness of breath, chest pain, leg swelling, or sudden vision changes. These could be signs of a serious blood clot.
- Tell your care team about all medications and supplements you take before using progesterone injection. Certain medications, such as ketoconazole, can affect progesterone levels and raise your risk of side effects.
- Progesterone injection comes in a multi-dose vial, meaning you'll take more than one dose from the same vial. Always use a new needle and syringe for each injection to prevent contamination.
- Storage: Keep progesterone injection at room temperature, even after opening the vial. Unless the product label says otherwise, throw away an opened multi-dose vial after 28 days.
How to use progesterone injection:
- Progesterone injection is given deep into a muscle, usually by a healthcare professional or a trained caregiver. It can be given at home after you or your caregiver learns how to inject correctly.
- Progesterone injection is commonly injected deep into the muscle of the upper outer buttock. Rotate injection sites with each dose to help reduce injection-site reactions.
- Throw away used syringes and needles in a sharps container. Don't put loose needles or syringes in the regular trash.
Risks and warnings for Progesterone injection
Progesterone injection can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Blood clots
- Risk factors: Taking progesterone injection with estrogens | Personal or family history of blood clots | High blood pressure | Diabetes | High cholesterol | Smoking | Obesity | Systemic lupus erythematosus (SLE)
Progesterone injection can raise your risk of blood clots, especially when used with estrogen medications. Blood clots can be life-threatening and lead to problems such as a heart attack, stroke.
Stop using progesterone injection and get medical help right away if you have leg pain or swelling, chest pain, trouble breathing, or sudden weakness or numbness.
Vision problems
Progesterone injection can cause retinal thrombosis, a blood clot that affects the eye. Stop using the medication and contact your prescriber right away if you have sudden vision changes or vision loss, double vision, a bulging eye, or a new migraine.
Fluid buildup
- Risk factors: Epilepsy | Migraine | Asthma | Heart problems | Kidney problems
Fluid retention: Progesterone injection can cause your body to hold on to extra fluid. This might worsen certain health conditions, including epilepsy, migraines, asthma, or heart or kidney problems. Your care team might monitor you more closely if you have one of these conditions.
Pneumonia
Rarely, progesterone injection can cause acute eosinophilic pneumonia, a serious lung inflammation. Symptoms can include fever, shortness of breath, and low oxygen levels and have typically started 2 to 4 weeks after beginning treatment.
Stop using progesterone injection and get medical help right away if you develop fever or trouble breathing during treatment.
Progesterone injection dosage
The average cost for 30 capsules of 100mg of Progesterone injection is $16.25 with a free GoodRx coupon. This is 66.40% off the average retail price of $48.36. 
Vial
Vial| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 10ml of 50mg/ml | 3 vials | $28.64 | $9.55 |
Interactions between Progesterone injection and other drugs
Progesterone injection may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Progesterone injection. Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abametapir
- Conivaptan
- Eslicarbazepine Acetate
- Fosnetupitant
- Netupitant
How much does Progesterone injection cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Progesterone injection contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Progesterone injection will not be safe for you to take.
- Blood clotting problems
- Liver problems
- Breast cancer
- Cancer of any genital organ (e.g., ovarian, cervical)
- Undiagnosed vaginal bleeding
- Missed abortion
- Allergy to sesame oil/seeds
What are alternatives to Progesterone injection?
There are a number of medications that your doctor can prescribe in place of Progesterone injection. Compare a few possible alternatives below.
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Progesterone injection images
