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Compare Lyllana vs. Divigel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lyllana (estradiol patch) and Divigel (estradiol gel) are both estrogen replacement therapies used to treat menopausal symptoms, such as hot flashes and night sweats. They are similar in that they both contain estradiol, a type of estrogen, and are used to relieve symptoms of menopause. However, they differ in their application methods and dosing schedules. Lyllana is a transdermal patch applied twice a week to the lower stomach or buttocks, while Divigel is a topical gel applied daily to the upper thigh. Lyllana is specifically indicated for preventing osteoporosis after menopause, whereas Divigel is not. Both medications are available by prescription only, but Divigel is available in both brand-name and generic forms. Common side effects of Lyllana include headaches and breast tenderness, while Divigel may cause vaginal yeast infections and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and they may require the addition of a progestin if you have a uterus.

  • Lyllana (estradiol patch)
    Estradiol gel (Divigel)
  • Lyllana (estradiol patch)
    Estradiol gel (Divigel)

  • Summary of Lyllana vs. Divigel

    Summary for Estrogen replacement
    Prescription only

    Lyllana (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, due to menopause. It also helps prevent bone loss (osteoporosis) after menopause. The patch is a type of hormone replacement therapy. One of the benefits of Lyllana (estradiol patch) compared to oral estrogen pills is that it might cause fewer side effects. But it can still cause common side effects like breast tenderness, headaches, and back pain.

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

  • Indications of Lyllana vs. Divigel

    Indications for
    •Hot flashes, night sweats, and flushes caused by menopause
    •Prevent osteoporosis that happens after menopause
    Indications for
    •Hot flashes and night sweats due to menopause

  • Pros and Cons of Lyllana vs. Divigel

    Pros and Const for Estrogen replacement
    Pros
    •Typically has fewer side effects than oral estrogen pills
    •Delivers a consistent dose of estrogen over time
    •Good option if you have trouble swallowing pills
    •Available in different strengths, allowing you to customize your dose
    Cons
    •Commonly causes headache, breast tenderness, and back pain
    •Need to apply a new patch twice a week
    •Raises your risk of certain cancers, blood clots, and strokes
    •Might need to take it with another hormone called progestin if you have a healthy uterus
    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming

  • Common Side Effects of Lyllana vs. Divigel

    Common Side Effects for
    •Headache (up to 50%)
    •Common cold symptoms (up to 20%)
    •Breast tenderness (up to 17%)
    •Sinus swelling (up to 13%)
    •Bleeding in-between periods (up to 11%)
    •Depression (up to 11%)
    •Back pain (up to 11%)
    •Sinus headache (up to 10%)
    •Indigestion (up to 9%)
    •Weight gain (up to 9%)
    •Joint pain (up to 9%)
    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)

  • Warnings of Lyllana vs. Divigel

    Common Side Effects for
    •Blood clots and related complications (e.g., heart attack, stroke)
    •Uterine (endometrial) cancer
    •Breast cancer
    •Ovarian cancer
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Severe allergic reactions
    •Worsening of other health conditions
    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer

  • Prices with our coupons for Lyllana vs. Divigel

    Learn more about Lyllana
    Learn more about Estradiol gel

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