Key takeaways
Premarin (conjugated estrogens) and Prempro (conjugated estrogens/medroxyprogesterone) are both used to treat menopausal symptoms, but they have some key differences. Premarin contains only estrogen and is used for a wider range of conditions, including certain cancers in advanced stages and low estrogen levels. Prempro, on the other hand, combines estrogen with medroxyprogesterone, a progestin that helps protect the uterus from damage and cancer. Prempro is only given to people with a uterus, while Premarin can be used by those without a uterus. Premarin is available in both oral and vaginal forms, whereas Prempro is only available as an oral tablet. Additionally, Prempro and Premarin are only available as brand-name medications as they both do not have generic versions. Both medications carry risks of serious side effects like cancer, blood clots, and strokes, especially with long-term use.
