Prempro (conjugated estrogens; medroxyprogesterone) is used as hormone replacement in menopausal women who still have their uterus, treat hot flashes and prevent osteoporosis. This drug is slightly more popular than other estrogen/progestin combinations.There are currently no generic alternatives to Prempro.
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Commonly Used Brand Name(s)Premphase, Prempro, Prempro Low Dose
Therapeutic ClassificationsEstrogen/Progestin Combination
- Blackbox Warning
- Proper Use
- Missed Dose
- Use & Storage
- Before Using
- Breast Feeding
- Drug Interactions
- Other Interactions
- Other Medical Problems
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Conjugated estrogens and medroxyprogesterone acetate combination is used to treat moderate to severe hot flashes, dryness in and around the vagina, and other symptoms of menopause. This medicine is also used to prevent osteoporosis (thinning of the bones) after menopause.
This medicine is available only with your doctor's prescription.
It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects.
This medicine comes with a patient information leaflet. Read and follow the instructions in the leaflet carefully. Ask your doctor if you have any questions.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For treatment of menopause symptoms and prevention of osteoporosis:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Use & StorageTOP
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Conjugated estrogens and medroxyprogesterone acetate combination is not recommended for children.
Although appropriate studies on the relationship of age to the effects of conjugated estrogens and medroxyprogesterone combination have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have certain unwanted effects (eg, breast cancer, stroke, or dementia), which may require caution in patients receiving this medicine.
|All Trimesters||X||Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical ProblemsTOP
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Abnormal vaginal bleeding or
- Antithrombin deficiency (blood clotting disorder) or
- Blood clots, or history of or
- Breast cancer, or history of or
- Deep vein thrombosis (blood clot in the leg), or history of or
- Heart attack, or history of or
- Hysterectomy (removal of the uterus), history of or
- Liver disease or
- Protein C deficiency (blood clotting disorder) or
- Protein S deficiency (blood clotting disorder) or
- Pulmonary embolism (blood clot in the lung), or history of or
- Stroke, or history of or
- Tumor (estrogen-dependent)—Should not be used in patients with these conditions.
- Asthma or
- Congestive heart failure or
- Diabetes or
- Edema (fluid retention or body swelling) or
- Epilepsy (seizures) or
- Gallbladder disease or
- Hereditary angioedema (swelling of the face, mouth, or throat) or
- Hypertension (high blood pressure) or
- Hypertriglyceridemia (high fats in the blood) or
- Hypothyroidism (an underactive thyroid) or
- Migraine headache or
- Porphyria (an enzyme problem) or
- Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects.
It is unlikely that a postmenopausal woman may become pregnant. But you should know that using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
Your risk of heart disease or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level.
Tell the medical doctor in charge that you are using this medicine before you have any kind of surgery. Your doctor will decide whether you should continue using this medicine.
Check with your doctor right away if a severe headache or a sudden loss of vision or any change in vision occurs while you are using this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
Pancreatitis may occur while you are using this medicine. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.
This medicine may cause serious types of allergic reactions, including anaphylaxis and angioedema. Anaphylaxis and angioedema can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat while you are using this medicine.
Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may cause the amount of medicine in the blood to be too high.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements.