Key takeaways
Prempro (conjugated estrogens/medroxyprogesterone) and Divigel (estradiol) are both used to treat menopausal symptoms, but they have some key differences. Prempro is a combination of estrogen and progestin, taken orally once a day, and is specifically for those with a uterus to prevent uterine cancer. It also helps with hot flashes, night sweats, and vaginal dryness, but it has serious risks like breast cancer and blood clots if used long-term. Divigel, on the other hand, is a topical gel applied to the skin once a day and only contains estrogen. It also treats hot flashes and night sweats, but if you have a uterus, you’ll need to take an additional progestin to lower the risk of uterine cancer. Divigel can be messy to apply and has the risk of transferring estrogen to others through skin contact. Divigel is available as a low-cost generic medication, whereas Prempro is only available as a brand-name medication, making it potentially expensive.
