Prempro vs. Bijuva for Menopause: Important Differences and Potential Risks.

Prempro

Bijuva

(estradiol / progesterone)

Summary for Prempro

Prescription only

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

Indications for Prempro

Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
Prevention of bone loss (osteoporosis) after menopause

Pros and Cons for Prempro

Pros

Only need to take once a day by mouth
Relieves multiple menopausal symptoms
Includes a progestin which helps protect your uterus
Lowers your risk of fractures by keeping your bones healthy

Cons

Raises your risk of certain cancers, blood clots, and strokes
Has more possible side effects than similar alternatives
Not safe if you have liver problems
Can't be used if you have a history of breast cancer

Common Side Effects for Prempro

Breast pain (up to 36%)
Headaches (up to 19%)
Stomach pain (up to 17%)
Menstrual cramps (up to 13%)
Gas (up to 8%)
Nausea (up to 8%)
Depression (up to 8%)
More vaginal discharge than usual (up to 8%)

Warnings for Prempro

Risk of blood clot
Breast cancer
Uterine (endometrial) cancer
Dementia
Gallbladder and liver problems
Changes in calcium levels in the blood
Vision problems
High triglycerides
Low thyroid hormone levels (hypothyroidism)
Fluid Retention
Severe allergic reaction
Worsening of other medical conditions

Summary for Bijuva

Prescription only

Bijuva (estradiol / progesterone) is a medication that combines two hormones into a single pill. It's used to treat moderate-to-severe vasomotor symptoms of menopause like hot flashes and night sweats. It's FDA approved for people with a uterus and have gone through menopause. This medication is a type of menopausal hormone therapy (MHT), also known as hormone replacement therapy (HRT). The dosage is 1 capsule by mouth each night with food. Side effects can include breast tenderness and headaches.

Indications for Bijuva

Moderate-to-severe vasomotor symptoms of menopause (e.g., hot flashes, night sweats) in people with a healthy uterus

Pros and Cons for Bijuva

Pros

Only taken once a day
Contains progesterone to help lower risk of uterine cancer from the estrogen

Cons

Can take a few weeks to feel the effects of the medication
Can cause breast tenderness

Common Side Effects for Bijuva

Breast tenderness (up to 10%)
Headache (up to 4%)
Nausea (up to 4%)
Vaginal discharge (up to 3%)
Vaginal bleeding (3%)
Pelvic pain (3%)

Warnings for Bijuva

Risk for blood clots and related complications (e.g., heart attack, stroke)
Risk for breast cancer
Risk for uterine cancer (also called endometrial cancer)
Possible risk of ovarian cancer
Risk for dementia
Liver or gallbladder problems in certain people
Vision problems
High triglyceride (fat) levels
Buildup of fluids in the body (fluid retention)
Low thyroid hormone levels in people who take thyroid hormone replacement therapy
Worsening of other medical conditions

Prices with our coupons for Prempro vs. Bijuva

Prempro1 package / 28 tablets of 0.3mg/1.5mg

$98.84$302.99

Get free coupons

More Information

Bijuva1 package / 30 capsules of 1mg/100mg

$85.00$313.73

Get free coupons

More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.

Compare
Prempro vs. Bijuva

Prempro

Bijuva

Summary for Prempro

Indications for Prempro

Pros and Cons for Prempro

Pros

Cons

Common Side Effects for Prempro

Warnings for Prempro

Summary for Bijuva

Indications for Bijuva

Pros and Cons for Bijuva

Pros

Cons

Common Side Effects for Bijuva

Warnings for Bijuva

Prices with our coupons for Prempro vs. Bijuva

Compare other Menopause drugs

Browse medications by letter

Good news for your inbox

Prempro

Bijuva

Summary for Prempro

Indications for Prempro

Pros and Cons for Prempro

Pros

Cons

Common Side Effects for Prempro

Warnings for Prempro

Summary for Bijuva

Indications for Bijuva

Pros and Cons for Bijuva

Pros

Cons

Common Side Effects for Bijuva

Warnings for Bijuva