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Bijuva vs. Prempro

Bijuva (estradiol / progesterone) is a medication that combines two hormones into a single pill. It's used to treat moderate-to-severe vasomotor symptoms of menopause like hot flashes and night sweats. It's FDA approved for people with a uterus and have gone through menopause. This medication is a type of menopausal hormone therapy (MHT), also known as hormone replacement therapy (HRT). The dosage is 1 capsule by mouth each night with food. Side effects can include breast tenderness and headaches.

• Moderate-to-severe vasomotor symptoms of menopause (e.g., hot flashes, night sweats) in people with a healthy uterus

• Breast tenderness (up to 10%)
• Headache (up to 4%)
• Nausea (up to 4%)
• Vaginal discharge (up to 3%)
• Vaginal bleeding (3%)
• Pelvic pain (3%)

• Risk for blood clots and related complications (e.g., heart attack, stroke)
• Risk for breast cancer
• Risk for uterine cancer (also called endometrial cancer)
• Possible risk of ovarian cancer
• Risk for dementia
• Liver or gallbladder problems in certain people
• Vision problems
• High triglyceride (fat) levels
• Buildup of fluids in the body (fluid retention)
• Low thyroid hormone levels in people who take thyroid hormone replacement therapy
• Worsening of other medical conditions

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
• Prevention of bone loss (osteoporosis) after menopause

• Breast pain (up to 36%)
• Headaches (up to 19%)
• Stomach pain (up to 17%)
• Menstrual cramps (up to 13%)
• Gas (up to 8%)
• Nausea (up to 8%)
• Depression (up to 8%)
• More vaginal discharge than usual (up to 8%)

• Risk of blood clot
• Breast cancer
• Uterine (endometrial) cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reaction
• Worsening of other medical conditions