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Prempro vs. Angeliq

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
• Prevention of bone loss (osteoporosis) after menopause

• Breast pain (up to 36%)
• Headaches (up to 19%)
• Stomach pain (up to 17%)
• Menstrual cramps (up to 13%)
• Gas (up to 8%)
• Nausea (up to 8%)
• Depression (up to 8%)
• More vaginal discharge than usual (up to 8%)

• Risk of blood clot
• Breast cancer
• Uterine (endometrial) cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reaction
• Worsening of other medical conditions

Angeliq (drospirenone / estradiol) is a combination hormone replacement therapy (HRT). It's used to relieve certain menopause symptoms, such as hot flashes and vaginal dryness. It contains 2 active ingredients: drospirenone (a progestin) and estradiol (an estrogen). Angeliq (drospirenone / estradiol) comes as a tablet that's taken by mouth once daily. Some side effects of this medication include breast pain, vaginal bleeding, belly ache, and weight gain. Angeliq (drospirenone / estradiol) is only available as a brand-name medication, not generic.

In females who have a healthy uterus:

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe symptoms of vulvar and vaginal atrophy, like vaginal dryness and irritation

• Breast pain or discomfort (up to 18%)
• Vaginal bleeding (up to 14%)
• Belly pain (up to 7%)

• Risk of blood clot
• Breast cancer
• Uterine or endometrial cancer
• Risk of dementia
• High blood potassium levels
• Liver or gallbladder problems
• Changes in calcium levels in the blood
• Vision problems
• High triglyceride (fat) levels
• Buildup of fluids in your body (fluid retention)
• Worsening of other medical conditions
• Interaction with other medications