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Duavee vs. Prempro

Duavee (conjugated estrogens / bazedoxifene) treats vasomotor symptoms of menopause like hot flashes and night sweats. It can also help prevent osteoporosis in people who've gone through menopause. This combination medication has two active ingredients. The estrogen helps restore estrogen levels in the body while the selective estrogen receptor modulator (SERM) helps protect against bone loss. The dosage is 1 tablet taken by mouth once every day. Side effects can include muscle spasms, nausea, and diarrhea.

• Treatment of moderate-to-severe vasomotor symptoms of menopause (e.g., hot flashes, night sweats)
• Prevention of osteoporosis in people who've gone through menopause

• Muscle spasms or twitching (9%)
• Nausea (8%)
• Diarrhea (8%)
• Indigestion (7%)
• Upper stomach pain (7%)
• Throat pain (7%)
• Dizziness (5%)
• Neck pain (5%)

• Risk for blood clots and related complications (e.g., heart attack, stroke)
• Risk for uterine cancer (also called endometrial cancer)
• Unknown risk for breast cancer or ovarian cancer
• Risk for dementia
• Gallbladder or liver problems in certain people
• Changes in vision
• High triglyceride (fat) levels
• Low thyroid hormone levels in people who take thyroid hormone replacement therapy
• Buildup of fluids in the body (fluid retention)
• Worsening of other medical conditions

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
• Prevention of bone loss (osteoporosis) after menopause

• Breast pain (up to 36%)
• Headaches (up to 19%)
• Stomach pain (up to 17%)
• Menstrual cramps (up to 13%)
• Gas (up to 8%)
• Nausea (up to 8%)
• Depression (up to 8%)
• More vaginal discharge than usual (up to 8%)

• Risk of blood clot
• Breast cancer
• Uterine (endometrial) cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reaction
• Worsening of other medical conditions