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Compare Imvexxy vs. Divigel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Estradiol vaginal insert (Vagifem, Yuvafem) and estradiol gel (Divigel) are both estrogen replacement medications used to treat symptoms of menopause, but they differ in their specific uses and forms. Estradiol vaginal insert is only used for vaginal symptoms of menopause. It's inserted into the vagina once daily for 2 weeks, then twice a week thereafter. Divigel is effective for bodywide menopause symptoms, such as hot flashes, and is applied to the skin on the upper thigh tonce daily. Both medications require a prescription and are available as lower-cost generics. Common side effects of the estradiol vaginal insert include vaginal yeast infections and back pain, while Divigel may cause breast tenderness and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and they should be used with caution, especially if you have a history of these conditions. You may also need an additional progestin with these medications to protect against the risk of uterine cancer.

  • Imvexxy
    Estradiol gel (Divigel)
  • Imvexxy
    Estradiol gel (Divigel)

  • Summary of Imvexxy vs. Divigel

    Summary for Estrogen replacement
    Prescription only

    Imvexxy (estradiol vaginal insert) is used to treat pain during sex due to vaginal thinning caused by menopause. It contains estradiol, a type of estrogen, which helps restore the vaginal tissues and reduce discomfort during sex. Imvexxy comes as a small softgel insert that's placed directly into the vagina without an applicator. It's available in a starter pack and a maintenance pack. You’ll typically use one insert twice a week after using it daily for the first 2 weeks. The most common side effect is headache.

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

  • Indications of Imvexxy vs. Divigel

    Indications for
    •Moderate to severe painful sex due to vaginal thinning from menopause
    Indications for
    •Hot flashes and night sweats due to menopause

  • Pros and Cons of Imvexxy vs. Divigel

    Pros and Const for Estrogen replacement
    Pros
    •FDA approved for pain during sex due to menopause
    •Comes in two different strengths
    •Can use it at any time of the day
    Cons
    •Not taken daily, so can be easy to forget a dose
    •Doesn't treat other menopause symptoms like hot flashes or night sweats
    •Must take a progestin if you have a uterus to lower your risk of uterine cancer
    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming

  • Common Side Effects of Imvexxy vs. Divigel

    Common Side Effects for
    •Headache (3-4%)
    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)

  • Warnings of Imvexxy vs. Divigel

    Common Side Effects for
    •Risk for blood clots and related complications
    •Risk for uterine cancer (also called endometrial cancer)
    •Risk for breast cancer
    •Risk for ovarian cancer
    •Risk for dementia
    •Gallbladder or liver problems in certain people
    •High triglyceride (fat) levels
    •Changes in calcium levels in certain people
    •Low thyroid hormone levels
    •Buildup of fluids in your body (fluid retention)
    •Worsening of certain other health conditions
    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer

  • Prices with our coupons for Imvexxy vs. Divigel

    Learn more about Imvexxy
    Learn more about Estradiol gel

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