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Compare Divigel vs. Progesterone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Estradiol gel (Divigel) and progesterone injection are both used to address hormone-related conditions, but they belong to different medication classes and have distinct uses. Divigel is an estrogen replacement therapy primarily used to treat menopausal symptoms such as hot flashes and night sweats. It is applied topically to the skin of the thigh once a day. Progesterone injection, on the other hand, is a progestin used to treat lack of menstrual periods and abnormal uterine bleeding due to hormone imbalance. It's also often used off-label as part of infertility treatments. It is typically injected into the thigh or butt muscle once daily. While both medications can cause breast tenderness and weight changes, Divigel is associated with risks such as blood clots and certain cancers, and should be used along with a progestin in most cases. Progesterone injection side effects include injection site pain, fluid retention, and breast tenderness.

  • Estradiol gel (Divigel)
    Progesterone
  • Estradiol gel (Divigel)
    Progesterone

  • Summary of Divigel vs. Progesterone

    Summary for Estrogen replacement
    Prescription only

    Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

    Summary for Progesterone
    Prescription only

    Progesterone is an injection used to treat people who aren't getting their period or have abnormal bleeding due to hormone imbalance. It belongs to a group of medications called progestins and works by replacing progesterone hormone that's naturally made in the body. The medication is typically injected into the muscle daily for 6-8 days in a row. Potential side effects include pain at the injection site, weight gain or weight loss, and breast tenderness.

  • Indications of Divigel vs. Progesterone

    Indications for
    •Hot flashes and night sweats due to menopause
    Indications for
    •Lack of menstrual periods due to hormone imbalance
    •Abnormal bleeding from the uterus due to hormone imbalance

  • Pros and Cons of Divigel vs. Progesterone

    Pros and Const for Estrogen replacement
    Pros
    •Relieves bothersome menopausal symptoms, such as hot flashes and night sweats
    •Applied directly to the skin on the thighs
    •Only need to use once a day
    •Available in multiple strengths to customize your dose
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Risk of exposing others to estrogen through skin contact
    •Might also need to take a progestin medication if you have a uterus
    •Need to wait for the gel to dry completely before bathing, showering, or swimming
    Pros and Const for Progesterone
    Pros
    •Helps to regulate your menstrual period
    •Only has to be taken once a day
    •Might be a good option for people who can't swallow pills
    Cons
    •Not safe if you have liver problems
    •Not a good option if you're allergic to sesame oil
    •Potentially raises your risk of serious blood clots

  • Common Side Effects of Divigel vs. Progesterone

    Common Side Effects for
    •Abnormal vaginal bleeding (4-10%)
    •Breast tenderness (3-9%)
    •Common cold symptoms (4-6%)
    •Upper respiratory tract infection (2-6%)
    •Vaginal yeast infection (1-6%)
    Common Side Effects for
    •Pain, swelling, and/or redness at the injection site
    •Breakthrough bleeding or spotting
    •Changes in menstrual flow
    •Changes in weight
    •Swelling
    •Vaginal discharge
    •Breast tenderness

  • Warnings of Divigel vs. Progesterone

    Common Side Effects for
    •Risk of blood clot
    •Uterine (endometrial) cancer
    •Breast cancer
    •Dementia
    •Gallbladder and liver problems
    •Changes in calcium levels in the blood
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Worsening of other medical conditions
    •Potential skin-to-skin transfer
    Common Side Effects for
    •Blood clots
    •Vision problems
    •Fluid buildup
    •Pneumonia

  • Prices with our coupons for Divigel vs. Progesterone

    Learn more about Estradiol gel
    Learn more about Progesterone

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