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Premarin vs. Estrace

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Premarin

 

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estradiol tablet

 

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Summary for Premarin

Prescription only

Premarin (conjugated estrogens) is an oral estrogen hormone tablet that's used to treat various conditions in adults. Most commonly, it relieves menopausal symptoms such as vaginal dryness and hot flashes. The medication is also used for treating low estrogen levels, certain advanced stages of breast or prostate cancers, and osteoporosis after menopause. Depending on what you're using it for, the medication can be taken daily or in cycles. Side effects include headache, stomach pain, nausea, and breast pain.

Indications for Premarin

Pros and Cons for Premarin

Pros

  • Relieves multiple menopausal symptoms
  • Available in multiple strengths, allowing you to customize your dose
  • Comes as a tablet that you take by mouth

Cons

  • Raises your risk of certain cancers, blood clots, and strokes
  • Some people might need to take it with another hormone called progestin
  • Not a first-choice medication for treating bone loss after menopause

Common Side Effects for Premarin

  • Headache (13-14%)
  • Abnormal vaginal bleeding (2-13%)
  • Breast pain (7-12%)
  • Stomach pain (8-11%)
  • Passing gas (4-6%)
  • Vaginal discharge (4-5%)
  • Back pain (3-5%)
  • General pain (3-5%)
  • Nausea (3-5%)
  • Insomnia (3-5%)
  • Depression (3-5%)
  • Weakness (2-5%)

Warnings for Premarin

  • Uterine (endometrial) cancer
  • Breast cancer
  • Blood clots and stroke
  • Heart disease and heart attacks
  • Dementia
  • Gallbladder and liver problems
  • Vision problems
  • High triglycerides
  • Low thyroid hormone levels (hypothyroidism)
  • Fluid Retention
  • Changes in calcium levels in the blood
  • Worsening of other health conditions

Summary for Estrace

Prescription only

Estradiol tablet is an estrogen hormone used to treat menopause symptoms like hot flashes, night sweats, and vaginal irritation. It also helps prevent bone loss (osteoporosis) after menopause. Though not as common, it's also FDA approved to treat certain advanced stages of breast and prostate cancer. The dose depends on your condition, but tablets are typically taken by mouth 1 to 3 times a day. Common side effects include nausea, vomiting, headache, and breast pain.

Indications for Estrace

Pros and Cons for Estrace

Pros

  • Relieves multiple menopausal symptoms
  • Available in many strengths, allowing you to customize your dose
  • Comes as a tablet that you take by mouth

Cons

  • Raises your risk of certain cancers, blood clots, and strokes
  • Some people might need to take it with another hormone called progestin
  • Not a first-choice medication for treating bone loss after menopause

Common Side Effects for Estrace

  • Headache
  • Breast pain
  • Abnormal vaginal bleeding or spotting
  • Stomach cramps or bloating
  • Nausea
  • Vomiting
  • Hair loss

Warnings for Estrace

  • Uterine (endometrial) cancer
  • Breast cancer
  • Blood clots and strokes
  • Heart disease and heart attacks
  • Dementia
  • Gallbladder and liver problems
  • Vision problems
  • High triglycerides
  • Low thyroid hormone levels (hypothyroidism)
  • Fluid Retention
  • Changes in calcium levels in the blood
  • Worsening of other health conditions

Prices with our coupons for Premarin vs. Estrace

Price Card Drug Icon
Premarin30 tablets / 0.625mg
$99.00$261.58
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Price Card Drug Icon
Estradiol90 tablets / 1mg
$19.72$71.63
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