Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Premarin vs. Estrace

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Premarin
    Estradiol tablet
  • Premarin
    Estradiol tablet

  • Summary of Premarin vs. Estrace

    Summary for Estrogen replacement
    Prescription only

    Premarin (conjugated estrogens) is an oral estrogen hormone tablet that's used to treat various conditions in adults. Most commonly, it relieves menopausal symptoms such as vaginal dryness and hot flashes. The medication is also used for treating low estrogen levels, certain advanced stages of breast or prostate cancers, and osteoporosis after menopause. Depending on what you're using it for, the medication can be taken daily or in cycles. Side effects include headache, stomach pain, nausea, and breast pain.

    Summary for Estrogen replacement
    Prescription only

    Estradiol tablet is an estrogen hormone used to treat menopause symptoms like hot flashes, night sweats, and vaginal irritation. It also helps prevent bone loss (osteoporosis) after menopause. Though not as common, it's also FDA approved to treat certain advanced stages of breast and prostate cancer. The dose depends on your condition, but tablets are typically taken by mouth 1 to 3 times a day. Common side effects include nausea, vomiting, headache, and breast pain.

  • Indications of Premarin vs. Estrace

    Indications for
    •Hot flashes, night sweats, and flushes caused by menopause
    •Vaginal dryness caused by menopause
    •Low estrogen levels due to certain conditions
    •Certain advanced stages of breast cancer
    •Certain advanced stages of prostate cancer
    •Prevention of bone loss (osteoporosis) after menopause
    Indications for
    •Hot flashes, night sweats, and flushes caused by menopause
    •Vaginal dryness caused by menopause
    •Low estrogen levels due to certain conditions
    •Certain advanced stages of breast cancer
    •Certain advanced stages of prostate cancer
    •Prevention of bone loss (osteoporosis) after menopause

  • Pros and Cons of Premarin vs. Estrace

    Pros and Const for Estrogen replacement
    Pros
    •Relieves multiple menopausal symptoms
    •Available in multiple strengths, allowing you to customize your dose
    •Comes as a tablet that you take by mouth
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Some people might need to take it with another hormone called progestin
    •Not a first-choice medication for treating bone loss after menopause
    Pros and Const for Estrogen replacement
    Pros
    •Relieves multiple menopausal symptoms
    •Available in many strengths, allowing you to customize your dose
    •Comes as a tablet that you take by mouth
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Some people might need to take it with another hormone called progestin
    •Not a first-choice medication for treating bone loss after menopause

  • Common Side Effects of Premarin vs. Estrace

    Common Side Effects for
    •Headache (13-14%)
    •Abnormal vaginal bleeding (2-13%)
    •Breast pain (7-12%)
    •Stomach pain (8-11%)
    •Passing gas (4-6%)
    •Vaginal discharge (4-5%)
    •Back pain (3-5%)
    •General pain (3-5%)
    •Nausea (3-5%)
    •Insomnia (3-5%)
    •Depression (3-5%)
    •Weakness (2-5%)
    Common Side Effects for
    •Headache
    •Breast pain
    •Abnormal vaginal bleeding or spotting
    •Stomach cramps or bloating
    •Nausea
    •Vomiting
    •Hair loss

  • Warnings of Premarin vs. Estrace

    Common Side Effects for
    •Uterine (endometrial) cancer
    •Breast cancer
    •Blood clots and stroke
    •Heart disease and heart attacks
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Changes in calcium levels in the blood
    •Worsening of other health conditions
    Common Side Effects for
    •Uterine (endometrial) cancer
    •Breast cancer
    •Blood clots and strokes
    •Heart disease and heart attacks
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Changes in calcium levels in the blood
    •Worsening of other health conditions

  • Prices with our coupons for Premarin vs. Estrace

    Learn more about Premarin
    Learn more about Estradiol tablet

Compare other Osteoporosis and Menopause drugs

Premarin Vaginal Cream vs ClimaraPremarin vs AloraPremarin vs ClimaraPremarin vs Depo EstradiolPremarin vs DivigelPremarin vs ElestrinPremarin vs EstracePremarin vs Estrace Vaginal CreamPremarin vs EstradiolPremarin vs Estradiol NorethindronePremarin vs Estradiol PatchPremarin vs EstringPremarin vs EvamistPremarin vs FemringPremarin vs MinivellePremarin vs Premarin Vaginal CreamPremarin vs PremproPremarin vs ProveraPremarin vs Vivelle DotYuvafem vs PremarinClimara vs FosamaxDepo Estradiol vs Estradiol ValerateEstring vs Depo EstradiolMinivelle vs ClimaraPrempro vs ClimaraPrempro vs Depo EstradiolProvera vs ClimaraProvera vs Depo EstradiolVivelle Dot vs ClimaraVivelle Dot vs Depo Estradiol
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.