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Prempro vs. Combipatch

Prempro is a combination estrogen/progestin medication that relieves menopausal symptoms like vaginal dryness and hot flashes. It's also used for preventing osteoporosis after menopause. This hormone replacement therapy is an option for people with a uterus. The medication is brand only since there is no generic available. Follow your prescriber's instructions for the correct dose. Prempro is taken by mouth once a day with the same dose each day. Premphase is also taken daily but contains two types of tablets: one with estrogen and one with conjugated estrogens plus medroxyprogesterone, taken on different days. Common side effects include breast pain, headaches, and menstrual cramps.

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe vaginal symptoms due to menopause, like vaginal dryness and irritation
• Prevention of bone loss (osteoporosis) after menopause

• Breast pain (up to 36%)
• Headaches (up to 19%)
• Stomach pain (up to 17%)
• Menstrual cramps (up to 13%)
• Gas (up to 8%)
• Nausea (up to 8%)
• Depression (up to 8%)
• More vaginal discharge than usual (up to 8%)

• Risk of blood clot
• Breast cancer
• Uterine (endometrial) cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Severe allergic reaction
• Worsening of other medical conditions

CombiPatch (estradiol / norethindrone) is a type of hormone replacement therapy. It treats symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. This combination medication also restores estrogen levels in people with medical conditions that cause low estrogen. It's a patch that's applied onto the skin twice a week. Common side effects include headache and breast pain.

In people who have a healthy uterus:

• Moderate-to-severe symptoms of menopause, like hot flashes, night sweats, vaginal dryness, and vaginal irritation
• Low estrogen levels caused by certain health conditions (e.g., ovaries aren't working as they should)

• Breast pain (25-31%)
• Menstrual cramps (20-21%)
• Headache (18-20%)
• Vaginitis (e.g., vaginal pain, itching, burning, or discharge; 6-13%)
• Weakness (8-12%)
• Breathing problems (7-12%)
• Irregular vaginal bleeding or other related menstrual issues (6-12%)
• Back pain (9-11%)
• Nausea (8-11%)
• Sore throat (4-10%)

• Risk for blood clots and other complications
• Risk for breast cancer
• Risk for uterine cancer (also called endometrial cancer)
• Risk for ovarian cancer
• Risk for dementia
• Gallbladder or liver problems in certain people
• Buildup of fluids in your body (fluid retention)
• High triglyceride (fat) levels
• Low thyroid hormone levels
• Changes in calcium levels in certain people