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Compare Premarin Vaginal Cream vs. Vivelle-Dot

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Premarin vaginal cream
    Vivelle-dot (estradiol patch)
  • Premarin vaginal cream
    Vivelle-dot (estradiol patch)

  • Summary of Premarin Vaginal Cream vs. Vivelle-Dot

    Summary for Estrogen replacement
    Prescription only

    Premarin (conjugated estrogens) vaginal cream is an estrogen hormone cream used to treat adults with vaginal symptoms due to menopause, such as vaginal dryness and pain during sex. Depending on what you're taking the vaginal cream for, the dosage can be different. You might apply it in cycles (daily for 3 weeks, then no cream for 1 week) or simply just twice a week. Common side effects include headache, pelvic pain, and breast pain.

    Summary for Estrogen replacement
    Prescription only

    Vivelle-Dot (estradiol patch) is a twice-weekly hormonal patch used to treat menopause symptoms and low estrogen levels. It also helps prevent bone loss (osteoporosis) in people who have gone through menopause. The patch is a form of hormone replacement therapy. The usual dose is one patch applied to the lower stomach or buttocks twice a week, or every 3 to 4 days. Side effects include headache, breast pain, and sinus swelling. </br> This twice weekly patch is also available as a generic called Dotti.

  • Indications of Premarin Vaginal Cream vs. Vivelle-Dot

    Indications for
    •Vaginal dryness and irritation
    •Pain during sex caused by menopause
    Indications for
    •Hot flashes, night sweats, and flushes caused by menopause
    •Vaginal dryness and irritation caused by menopause
    •Low estrogen levels due to certain conditions
    •Prevention of osteoporosis after menopause

  • Pros and Cons of Premarin Vaginal Cream vs. Vivelle-Dot

    Pros and Const for Estrogen replacement
    Pros
    •Is applied directly into the vagina to relieve symptoms locally
    •Good option if for those who have trouble swallow pills
    •Smaller amounts are absorbed into the body compared to tablets or injections
    Cons
    •Applying the cream can be messy
    •Need to remember stop taking it for a week if your dosage is in cycles
    •Can take several weeks to improve symptoms
    Pros and Const for Estrogen replacement
    Pros
    •Typically has fewer side effects than oral estrogen pills
    •Relieves multiple menopause symptoms
    •Good option if you have trouble swallowing pills
    •Available in different strengths, allowing you to customize your dose
    Cons
    •Commonly causes headache, breast pain, and sinus swelling
    •Need to apply a new patch twice a week
    •Raises your risk of certain cancers, blood clots, and strokes
    •Might need to take it with another hormone called progestin if you have a healthy uterus

  • Common Side Effects of Premarin Vaginal Cream vs. Vivelle-Dot

    Common Side Effects for
    •Breast pain (2-5%)
    •Headache (2-4%)
    •Pelvic pain (3%)
    •Vaginal discharge (2-3%)
    Common Side Effects for
    •Headache (up to 50%)
    •Common cold symptoms (up to 20%)
    •Breast tenderness (up to 17%)
    •Sinus swelling (up to 13%)
    •Bleeding in-between periods (up to 11%)
    •Depression (up to 11%)
    •Back pain (up to 11%)
    •Sinus headache (up to 10%)
    •Indigestion (up to 9%)
    •Weight gain (up to 9%)
    •Joint pain (up to 9%)

  • Warnings of Premarin Vaginal Cream vs. Vivelle-Dot

    Common Side Effects for
    •Uterine (endometrial) cancer
    •Breast cancer
    •Blood clots and stroke
    •Heart disease and heart attacks
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Changes in calcium levels in the blood
    •Worsening of other health conditions
    Common Side Effects for
    •Blood clots and related complications (e.g., heart attack, stroke)
    •Uterine (endometrial) cancer
    •Breast cancer
    •Ovarian cancer
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Severe allergic reactions
    •Worsening of other health conditions

  • Prices with our coupons for Premarin Vaginal Cream vs. Vivelle-Dot

    Learn more about Premarin vaginal cream
    Learn more about Vivelle-dot

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