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Compare Evamist vs. Provera

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Evamist (topical estradiol spray) and Provera (medroxyprogesterone) are both medications used in hormone therapy, but they belong to different classes and have distinct uses. Evamist is an estrogen replacement therapy used to treat moderate-to-severe vasomotor symptoms of menopause, such as hot flashes and night sweats. It is applied as a topical spray on the forearm. Provera, on the other hand, is a progestin taken orally to regulate menstrual cycles and protect the uterus in postmenopausal women taking estrogen therapy. While Evamist is applied once daily, Provera is typically only taken for specific days each month, depending on the condition being treated. Evamist does not have a generic version, whereas Provera is available in brand-name and generic form. Common side effects of Evamist include headaches and breast tenderness, while Provera may cause spotting or breakthrough bleeding. Both medications can increase the risk of blood clots, heart attacks, and strokes However, Provera is specifically used to lower the risk of endometrial cancer in women taking estrogen.

  • Evamist (estradiol)
    Medroxyprogesterone (Provera)
  • Evamist (estradiol)
    Medroxyprogesterone (Provera)

  • Summary of Evamist vs. Provera

    Summary for Estrogen replacement
    Prescription only

    Evamist (estradiol) is a topical hormone spray that helps relieve the hot flashes and night sweats caused by menopause. It's a hormone replacement therapy (HRT) that's sprayed onto the skin of your inner forearm once a day. The typical dose ranges from 1 to 3 sprays daily, depending on your symptoms. Some potential side effects of this medication include headache, tender breasts, and back pain.

    Summary for Progestin
    Prescription only

    Medroxyprogesterone (Provera) can help make your menstrual cycles more regular. It also helps protect the uterus from harm in people who've gone through menopause and are taking estrogen replacement medications. When taken with estrogen therapy, it has some serious risks that you should consider if you need treatment for a long time.

  • Indications of Evamist vs. Provera

    Indications for
    •Moderate-to-severe vasomotor symptoms of menopause, like hot flashes and night sweats
    Indications for
    •Lack of menstrual periods due to hormone imbalance
    •Irregular periods due to hormone imbalance
    •Protection of the uterus in postmenopausal women who are taking estrogen medications

  • Pros and Cons of Evamist vs. Provera

    Pros and Const for Estrogen replacement
    Pros
    •Dries within 2 minutes, doesn't need to be rubbed in
    •Possible option if you can't swallow pills
    •Only needs to be applied once a day
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Need to use with progestin to lower your risk of uterine cancer (in females who have uterus)
    •Must cover with clothing to prevent exposure to others
    Pros and Const for Progestin
    Pros
    •Taken once a day
    •Helps protect the uterus from damage if taking estrogen medications after menopause
    •A good alternative to progesterone (Prometrium) if you have a peanut allergy
    Cons
    •Need to remember to take on certain days of the month
    •Can have spotting or breakthrough bleeding, even if you've gone through menopause
    •Shouldn't be used in people with liver problems

  • Common Side Effects of Evamist vs. Provera

    Common Side Effects for
    •Headache (up to 12%)
    •Breast tenderness (up to 7%)
    •Nipple pain (up to 7%)
    •Cold-like symptoms (up to 5%)
    •Back pain (up to 5%)
    •Joint pain (up to 4%)
    Common Side Effects for
    •Spotting or breakthrough bleeding
    •Heavier or lighter periods
    •Breast tenderness
    •Nausea

  • Warnings of Evamist vs. Provera

    Common Side Effects for
    •Uterine or endometrial cancer
    •Breast cancer
    •Blood clots, heart attacks, and strokes
    •Risk of dementia
    •Risk of harm in children (accidental contact with medication)
    •Gallbladder problems
    •Higher risk of side effects
    •Vision problems
    •High triglycerides
    •Changes in calcium levels in the blood
    •Low thyroid hormone levels (hypothyroidism)
    •Swelling from fluids
    •Worsening of other medical conditions
    Common Side Effects for
    •When taken with estrogen medications:
    •Blood clots and their complications (heart attack, stroke)
    •Breast cancer
    •Dementia
    •Uterine and ovarian cancer
    •Vision problems
    •Higher blood pressure and cholesterol levels
    •Swelling (fluid buildup)

  • Prices with our coupons for Evamist vs. Provera

    Learn more about Evamist
    Learn more about Medroxyprogesterone

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