Key takeaways
Climara (estradiol) and Estring (estradiol) are both estrogen replacement therapies, but they differ in their forms and uses. Climara is a transdermal patch applied to the skin once or twice a week, while Estring is a vaginal ring that needs to be replaced every three months. Climara treats multiple menopause symptoms, including hot flashes and night sweats, and can also help prevent osteoporosis. In contrast, Estring specifically targets vaginal dryness, burning, and irritation due to menopause. Climara may require you to avoid swimming if using the once-weekly patch, whereas Estring does not have such restrictions. Additionally, Climara is available in both generic and brand-name forms, which can make it more affordable, while Estring is only available as a brand-name medication. Both treatments may require the use of a progestin if you still have your uterus to lower the risk of uterine cancer, but this is less likely with Estring due to its lower estrogen dose.
