Key takeaways
Minivelle (estradiol) and Climara (estradiol) are both estrogen replacement patches used to treat symptoms of menopause, such as hot flashes and night sweats, and to prevent bone loss (osteoporosis) after menopause. They are both transdermal patches applied to the skin. However, there are some differences between the two. Minivelle is applied twice a week, while Climara is applied once a week. Minivelle is only available as a branded medication, while Climara also comes as a lower-cost generic. Common side effects of both medications include headache, breast pain, and back pain. Both medications carry risks of serious side effects like blood clots and certain cancers. If you have a uterus, you may also need to take a progestin with either Minivelle or Climara.
