Key takeaways
Minivelle (estradiol patch) and Divigel (estradiol gel) are both estrogen replacement therapies used to treat menopausal symptoms like hot flashes and night sweats. They are in the same medication class and work by replacing the estrogen your body loses during menopause. However, they have some important differences. Minivelle is a transdermal patch applied twice a week to the lower stomach or buttocks, while Divigel is a topical gel applied daily to the upper thigh. Both medications are only available in a branded version. Common side effects of Minivelle include headaches and breast tenderness, while Divigel may cause vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and you might need to take a progestin if you have a uterus.
