Head-to-head comparisons of medication uses, side effects, warnings, and more.
Minivelle (estradiol patch)
Estradiol gel (Divigel)
Minivelle (estradiol patch)
Estradiol gel (Divigel)
Summary of Minivelle vs. Divigel
Summary for Estrogen replacement
Prescription only
Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. The usual dose is one patch applied to the lower stomach or buttocks twice a week, or every 3 to 4 days. Potential side effects include headache, breast tenderness, and back pain.
Summary for Estrogen replacement
Prescription only
Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.