Key takeaways
Alendronate (Fosamax) and raloxifene (Evista) are both used to treat osteoporosis, but they work differently and have different uses. Alendronate (Fosamax) is a bisphosphonate that slows bone breakdown and is available in both generic and brand forms. It can be taken daily or weekly and is also used to treat Paget's disease. Raloxifene (Evista), on the other hand, is a selective estrogen receptor modulator (SERM) that acts like estrogen in bones to prevent bone loss. It is also available as a brand-name and generic medication. It is taken once daily and also helps lower the risk of invasive breast cancer in postmenopausal women. Alendronate (Fosamax) can cause stomach issues and serious jaw problems, while raloxifene (Evista) can lead to blood clots and hot flashes. Additionally, raloxifene (Evista) is not recommended for women who haven't gone through menopause or have a history of blood clots.
