Key takeaways
Alendronate (Fosamax) and risedronate (Actonel) are both bisphosphonates used to treat and prevent osteoporosis. Alendronate is available in multiple forms, including tablets, oral solutions, and effervescent tablets, and can be taken daily or weekly. Risedronate also offers various dosing options, including daily, weekly, and monthly, and has a delayed-release form called Atelvia, which is taken after breakfast. Alendronate must be taken on an empty stomach, while Atelvia can be taken with food, which may reduce stomach pain. Both medications can cause serious side effects like jaw problems and stomach irritation, but risedronate has a higher incidence of common side effects such as infections and back pain. Additionally, both medications are not recommended for people with severe kidney disease.
