Evenity vs. Boniva for Osteoporosis: Important Differences and Potential Risks.

Evenity

(romosozumab)

Ibandronate

(Boniva)

Summary for Evenity

Prescription only

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

Indications for Evenity

Treatment of osteoporosis in certain women after menopause
- With high risk of fracture
- Who can’t take other medications for bone loss
- Who tried other medications for bone loss that didn’t work

Pros and Cons for Evenity

Pros

Helps with bone growth and prevents bone loss at the same time
Given just once a month
Only need 1 year of treatment

Cons

Needs to be injected
Must go to the medical office for each injection
Bone mineral density eventually goes back to where it was before after stopping the medication

Common Side Effects for Evenity

Joint pain (up to 13%)
Headache (up to 7%)

Warnings for Evenity

Risk of heart attack, stroke, or heart-related death
Low calcium levels (hypocalcemia)
Risk of problems in the jawbone (osteonecrosis of the jaw)
Risk of fractures in the thigh

Summary for Boniva

Prescription only

Ibandronate (Boniva) is used to treat and prevent osteoporosis (bone loss or weakening). It can help improve bone mineral density (BMD) and lower the risk of back fractures. Unlike other similar osteoporosis medications, ibandronate (Boniva) is only approved for women who have gone through menopause.

Indications for Boniva

Osteoporosis in women who have gone through menopause (postmenopause)

Pros and Cons for Boniva

Pros

Taken once a month as a tablet
Also available as an IV infusion given by a healthcare provider every 3 months if there are too many stomach problems from the tablet
Helps lower the risk of back fractures
Available as a lower-cost generic medication

Cons

Risk of many side effects, including stomach pain and severe jaw problems
Not approved for osteoporosis caused by long-term corticosteroid use, men with osteoporosis, or people with Paget's disease
Not recommended for people with severe kidney disease

Common Side Effects for Boniva

Stomach pain (8%)
Heartburn (6%)
Joint pain (6%)
Back pain (5%)
Nausea (5%)
Diarrhea (5%)
Arm or leg pain (4%)
Headache (3%)
Muscle pain (2%)

Warnings for Boniva

Stomach and esophagus irritation and ulcers
Breakdown of the jawbone (osteonecrosis)
Severe bone, joint, or muscle pain
Leg bone fractures
Low calcium in the blood

Prices with our coupons for Evenity vs. Boniva

Evenity1 carton / 2 syringes of 105mg/1.17ml

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Ibandronate1 dose pack / 3 tablets of 150mg

$24.27$248.81

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Evenity vs. Boniva

Evenity

Ibandronate

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity

Summary for Boniva

Indications for Boniva

Pros and Cons for Boniva

Pros

Cons

Common Side Effects for Boniva

Warnings for Boniva

Prices with our coupons for Evenity vs. Boniva

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Evenity

Ibandronate

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity

Summary for Boniva

Indications for Boniva

Pros and Cons for Boniva

Pros

Cons

Common Side Effects for Boniva

Warnings for Boniva