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Evenity vs. Boniva

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh

Ibandronate (Boniva) is used to treat and prevent osteoporosis (bone loss or weakening). It can help improve bone mineral density (BMD) and lower the risk of back fractures. Unlike other similar osteoporosis medications, ibandronate (Boniva) is only approved for women who have gone through menopause.

• Osteoporosis in women who have gone through menopause (postmenopause)

• Stomach pain (8%)
• Heartburn (6%)
• Joint pain (6%)
• Back pain (5%)
• Nausea (5%)
• Diarrhea (5%)
• Arm or leg pain (4%)
• Headache (3%)
• Muscle pain (2%)

• Stomach and esophagus irritation and ulcers
• Breakdown of the jawbone (osteonecrosis)
• Severe bone, joint, or muscle pain
• Leg bone fractures
• Low calcium in the blood