Evenity vs. Reclast for Osteoporosis: Important Differences and Potential Risks.

Evenity

(romosozumab)

Reclast

(zoledronic acid)

Summary for Evenity

Prescription only

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

Indications for Evenity

Treatment of osteoporosis in certain women after menopause
- With high risk of fracture
- Who can’t take other medications for bone loss
- Who tried other medications for bone loss that didn’t work

Pros and Cons for Evenity

Pros

Helps with bone growth and prevents bone loss at the same time
Given just once a month
Only need 1 year of treatment

Cons

Needs to be injected
Must go to the medical office for each injection
Bone mineral density eventually goes back to where it was before after stopping the medication

Common Side Effects for Evenity

Joint pain (up to 13%)
Headache (up to 7%)

Warnings for Evenity

Risk of heart attack, stroke, or heart-related death
Low calcium levels (hypocalcemia)
Risk of problems in the jawbone (osteonecrosis of the jaw)
Risk of fractures in the thigh

Summary for Reclast

Prescription only

Reclast (zoledronic acid) is used to treat osteoporosis. It's only available as an intravenous (IV) infusion that's given at a clinic or your provider's office. The medication is an option for postmenopausal women with osteoporosis who can't take bisphosphonates by mouth or for those at very high fracture risk. Reclast (zoledronic acid) is a long-lasting medication, so the dosing isn't often (either one-time only, once a year, or once every 2 years). It can cause side effects like muscle and joint pain, headache, and fever. This medication is available under the brand name Reclast and as a generic.

Indications for Reclast

Osteoporosis in women who have gone through menopause (postmenopause)
Osteoporosis in men
Osteoporosis caused by long-term use of corticosteroids
Paget's disease

Pros and Cons for Reclast

Pros

Lowers the risk of fractures in different parts of the body, including the hip and back
Infusions are one-time only, once a year, or once every 2 years
Can freely choose when to eat, drink, or take other medications
Can use if you can't take other bisphosphonates because of trouble swallowing or too much stomach pain
Can consider using for postmenopausal women with osteoporosis who have very high fracture risk

Cons

Only available as an IV infusion that's given at a clinic or provider's office
Risk of many side effects, including joint or muscle pain and severe jaw problems
Risk of side effects like fever, pain, and chills after each infusion
Might cause breathing problems in people allergic to aspirin

Common Side Effects for Reclast

Joint pain (up to 24%)
Fever (up to 18%)
Higher blood pressure (up to 13%)
Headache (up to 12%)
Muscle pain (up to 12%)
Arm or leg pain (up to 11%)
Arthritis (up to 9%)
Flu-like symptoms (up to 9%)
Nausea (up to 9%)
Dizziness (up to 8%)
Shoulder pain (up to 7%)
Bone pain (up to 6%)
Diarrhea (up to 6%)
Vomiting (up to 5%)

Warnings for Reclast

Breakdown of the jaw (osteonecrosis)
Low calcium in the blood
Kidney damage
Leg bone fractures
Severe bone, joint, or muscle pain
Harm to unborn baby

Prices with our coupons for Evenity vs. Reclast

Evenity1 carton / 2 syringes of 105mg/1.17ml

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Zoledronic Acid1 vial / 5ml of 4mg/5ml

$17.68$991.88

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Evenity vs. Reclast

Evenity

Reclast

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity

Summary for Reclast

Indications for Reclast

Pros and Cons for Reclast

Pros

Cons

Common Side Effects for Reclast

Warnings for Reclast

Prices with our coupons for Evenity vs. Reclast

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Evenity

Reclast

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity

Summary for Reclast

Indications for Reclast

Pros and Cons for Reclast

Pros

Cons

Common Side Effects for Reclast

Warnings for Reclast