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Evenity vs. Reclast

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh

Reclast (zoledronic acid) is used to treat osteoporosis. It's only available as an intravenous (IV) infusion that's given at a clinic or your provider's office. The medication is an option for postmenopausal women with osteoporosis who can't take bisphosphonates by mouth or for those at very high fracture risk. Reclast (zoledronic acid) is a long-lasting medication, so the dosing isn't often (either one-time only, once a year, or once every 2 years). It can cause side effects like muscle and joint pain, headache, and fever. This medication is available under the brand name Reclast and as a generic.

• Osteoporosis in women who have gone through menopause (postmenopause)
• Osteoporosis in men
• Osteoporosis caused by long-term use of corticosteroids
• Paget's disease

• Joint pain (up to 24%)
• Fever (up to 18%)
• Higher blood pressure (up to 13%)
• Headache (up to 12%)
• Muscle pain (up to 12%)
• Arm or leg pain (up to 11%)
• Arthritis (up to 9%)
• Flu-like symptoms (up to 9%)
• Nausea (up to 9%)
• Dizziness (up to 8%)
• Shoulder pain (up to 7%)
• Bone pain (up to 6%)
• Diarrhea (up to 6%)
• Vomiting (up to 5%)

• Breakdown of the jaw (osteonecrosis)
• Low calcium in the blood
• Kidney damage
• Leg bone fractures
• Severe bone, joint, or muscle pain
• Harm to unborn baby