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Compare Evenity vs. Reclast

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Evenity (romosozumab)
    Reclast (zoledronic acid)
  • Evenity (romosozumab)
    Reclast (zoledronic acid)

  • Summary of Evenity vs. Reclast

    Summary for Sclerostin inhibitor
    Prescription only

    Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

    Summary for Bisphosphonate
    Prescription only

    Reclast (zoledronic acid) is used to treat osteoporosis. It's only available as an intravenous (IV) infusion that's given at a clinic or your provider's office. The medication is an option for postmenopausal women with osteoporosis who can't take bisphosphonates by mouth or for those at very high fracture risk. Reclast (zoledronic acid) is a long-lasting medication, so the dosing isn't often (either one-time only, once a year, or once every 2 years). It can cause side effects like muscle and joint pain, headache, and fever. This medication is available under the brand name Reclast and as a generic.

  • Indications of Evenity vs. Reclast

    Indications for
    •Treatment of osteoporosis in certain women after menopause
    •With high risk of fracture
    •Who can’t take other medications for bone loss
    •Who tried other medications for bone loss that didn’t work
    Indications for
    •Osteoporosis in women who have gone through menopause (postmenopause)
    •Osteoporosis in men
    •Osteoporosis caused by long-term use of corticosteroids
    •Paget's disease

  • Pros and Cons of Evenity vs. Reclast

    Pros and Const for Sclerostin inhibitor
    Pros
    •Helps with bone growth and prevents bone loss at the same time
    •Given just once a month
    •Only need 1 year of treatment
    Cons
    •Needs to be injected
    •Must go to the medical office for each injection
    •Bone mineral density eventually goes back to where it was before after stopping the medication
    Pros and Const for Bisphosphonate
    Pros
    •Lowers the risk of fractures in different parts of the body, including the hip and back
    •Infusions are one-time only, once a year, or once every 2 years
    •Can freely choose when to eat, drink, or take other medications
    •Can use if you can't take other bisphosphonates because of trouble swallowing or too much stomach pain
    •Can consider using for postmenopausal women with osteoporosis who have very high fracture risk
    Cons
    •Only available as an IV infusion that's given at a clinic or provider's office
    •Risk of many side effects, including joint or muscle pain and severe jaw problems
    •Risk of side effects like fever, pain, and chills after each infusion
    •Might cause breathing problems in people allergic to aspirin

  • Common Side Effects of Evenity vs. Reclast

    Common Side Effects for
    •Joint pain (up to 13%)
    •Headache (up to 7%)
    Common Side Effects for
    •Joint pain (up to 24%)
    •Fever (up to 18%)
    •Higher blood pressure (up to 13%)
    •Headache (up to 12%)
    •Muscle pain (up to 12%)
    •Arm or leg pain (up to 11%)
    •Arthritis (up to 9%)
    •Flu-like symptoms (up to 9%)
    •Nausea (up to 9%)
    •Dizziness (up to 8%)
    •Shoulder pain (up to 7%)
    •Bone pain (up to 6%)
    •Diarrhea (up to 6%)
    •Vomiting (up to 5%)

  • Warnings of Evenity vs. Reclast

    Common Side Effects for
    •Risk of heart attack, stroke, or heart-related death
    •Low calcium levels (hypocalcemia)
    •Risk of problems in the jawbone (osteonecrosis of the jaw)
    •Risk of fractures in the thigh
    Common Side Effects for
    •Breakdown of the jaw (osteonecrosis)
    •Low calcium in the blood
    •Kidney damage
    •Leg bone fractures
    •Severe bone, joint, or muscle pain
    •Harm to unborn baby

  • Prices with our coupons for Evenity vs. Reclast

    Learn more about Evenity
    Learn more about Reclast

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