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Compare Prolia vs. Evenity

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Prolia (denosumab)
    Evenity (romosozumab)
  • Prolia (denosumab)
    Evenity (romosozumab)

  • Summary of Prolia vs. Evenity

    Summary for Monoclonal antibody
    Prescription only

    Prolia (denosumab) is an injection that's used to treat osteoporosis in adults at high risk of fracture. It's also for those at high risk of fractures from certain cancer medications. It works as a monoclonal antibody called a RANKL inhibitor to strengthen your bones. Prolia (denosumab) is a convenient option because you only need an injection every 6 months. It's injected under the skin by a healthcare professional at a medical office. Side effects include back and muscle pain. It also has a risk of causing dangerously low calcium levels.

    Summary for Sclerostin inhibitor
    Prescription only

    Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

  • Indications of Prolia vs. Evenity

    Indications for
    •Osteoporosis in women who've gone through menopause and at high risk of fracture
    •Osteoporosis in men at high risk of fracture
    •Osteoporosis caused by steroid medications in people at high risk of fracture
    •Bone loss in men at high risk of fracture taking certain medications for prostate cancer
    •Bone loss in women at high risk of fracture taking certain breast cancer medications
    Indications for
    •Treatment of osteoporosis in certain women after menopause
    •With high risk of fracture
    •Who can’t take other medications for bone loss
    •Who tried other medications for bone loss that didn’t work

  • Pros and Cons of Prolia vs. Evenity

    Pros and Const for Monoclonal antibody
    Pros
    •Works well at preventing bone loss, which lowers your risk of breaking a bone
    •Only given once every 6 months, which is less often than most other osteoporosis medications
    •An alternative option for people who can't take bisphosphonates like alendronate (Fosamax)
    •A good option for postmenopausal women at very high risk of fractures
    Cons
    •Must go to the medical office to get the injection
    •Must take with calcium and vitamin D supplements
    •Can cause bone and muscle pain
    •Not safe during pregnancy
    Pros and Const for Sclerostin inhibitor
    Pros
    •Helps with bone growth and prevents bone loss at the same time
    •Given just once a month
    •Only need 1 year of treatment
    Cons
    •Needs to be injected
    •Must go to the medical office for each injection
    •Bone mineral density eventually goes back to where it was before after stopping the medication

  • Common Side Effects of Prolia vs. Evenity

    Common Side Effects for
    •Back pain (35%)
    •Pain in the arm or leg (12%)
    •Muscle, bone, or joint pain (up to 8%)
    •High cholesterol levels (7%)
    •Pain or discomfort while urinating and other symptoms of a bladder infection (6%)
    •Sensation that the room is spinning (5%)
    •Swelling in the hands or feet (5%)
    •Upper respiratory tract infection (5%)
    Common Side Effects for
    •Joint pain (up to 13%)
    •Headache (up to 7%)

  • Warnings of Prolia vs. Evenity

    Common Side Effects for
    •Dangerously low calcium levels
    •Risk of fractures in the thigh bone
    •Risk of spine fractures after stopping Prolia (denosumab)
    •Risk of serious infections
    •Risk of problems in the jawbone
    •Serious allergic reactions and skin reactions
    •Severe bone, muscle, or joint pain
    •Don't take with Xgeva (denosumab)
    Common Side Effects for
    •Risk of heart attack, stroke, or heart-related death
    •Low calcium levels (hypocalcemia)
    •Risk of problems in the jawbone (osteonecrosis of the jaw)
    •Risk of fractures in the thigh

  • Prices with our coupons for Prolia vs. Evenity

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