Prolia vs. Evenity for Osteoporosis: Important Differences and Potential Risks.

Prolia

(denosumab)

Evenity

(romosozumab)

Summary for Prolia

Prescription only

Prolia (denosumab) is an injection that's used to treat osteoporosis in adults at high risk of fracture. It's also for those at high risk of fractures from certain cancer medications. It works as a monoclonal antibody called a RANKL inhibitor to strengthen your bones. Prolia (denosumab) is a convenient option because you only need an injection every 6 months. It's injected under the skin by a healthcare professional at a medical office. Side effects include back and muscle pain. It also has a risk of causing dangerously low calcium levels.

Indications for Prolia

Osteoporosis in women who've gone through menopause and at high risk of fracture
Osteoporosis in men at high risk of fracture
Osteoporosis caused by steroid medications in people at high risk of fracture
Bone loss in men at high risk of fracture taking certain medications for prostate cancer
Bone loss in women at high risk of fracture taking certain breast cancer medications

Pros and Cons for Prolia

Pros

Works well at preventing bone loss, which lowers your risk of breaking a bone
Only given once every 6 months, which is less often than most other osteoporosis medications
An alternative option for people who can't take bisphosphonates like alendronate (Fosamax)
A good option for postmenopausal women at very high risk of fractures

Cons

Must go to the medical office to get the injection
Must take with calcium and vitamin D supplements
Can cause bone and muscle pain
Not safe during pregnancy

Common Side Effects for Prolia

Back pain (35%)
Pain in the arm or leg (12%)
Muscle, bone, or joint pain (up to 8%)
High cholesterol levels (7%)
Pain or discomfort while urinating and other symptoms of a bladder infection (6%)
Sensation that the room is spinning (5%)
Swelling in the hands or feet (5%)
Upper respiratory tract infection (5%)

Warnings for Prolia

Dangerously low calcium levels
Risk of fractures in the thigh bone
Risk of spine fractures after stopping Prolia (denosumab)
Risk of serious infections
Risk of problems in the jawbone
Serious allergic reactions and skin reactions
Severe bone, muscle, or joint pain
Don't take with Xgeva (denosumab)

Summary for Evenity

Prescription only

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

Indications for Evenity

Treatment of osteoporosis in certain women after menopause
- With high risk of fracture
- Who can’t take other medications for bone loss
- Who tried other medications for bone loss that didn’t work

Pros and Cons for Evenity

Pros

Helps with bone growth and prevents bone loss at the same time
Given just once a month
Only need 1 year of treatment

Cons

Needs to be injected
Must go to the medical office for each injection
Bone mineral density eventually goes back to where it was before after stopping the medication

Common Side Effects for Evenity

Joint pain (up to 13%)
Headache (up to 7%)

Warnings for Evenity

Risk of heart attack, stroke, or heart-related death
Low calcium levels (hypocalcemia)
Risk of problems in the jawbone (osteonecrosis of the jaw)
Risk of fractures in the thigh

Prices with our coupons for Prolia vs. Evenity

Prolia1 syringe / 1ml of 60mg/ml

$1,870.20$2,460.96

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Evenity1 carton / 2 syringes of 105mg/1.17ml

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Prolia vs. Evenity

Prolia

Evenity

Summary for Prolia

Indications for Prolia

Pros and Cons for Prolia

Pros

Cons

Common Side Effects for Prolia

Warnings for Prolia

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity

Prices with our coupons for Prolia vs. Evenity

Compare other Osteoporosis drugs

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Prolia

Evenity

Summary for Prolia

Indications for Prolia

Pros and Cons for Prolia

Pros

Cons

Common Side Effects for Prolia

Warnings for Prolia

Summary for Evenity

Indications for Evenity

Pros and Cons for Evenity

Pros

Cons

Common Side Effects for Evenity

Warnings for Evenity