RANKL inhibitors are used to treat conditions like osteoporosis, weakened bones caused by cancer, noncancerous bone tumors. They work by blocking a protein called RANKL, which helps to reduce bone breakdown and increase bone strength. These medications are available in injectable forms. Examples include denosumab (Prolia) and denosumab (Xgeva). You will receive these injections from a healthcare professional, usually every six months or as directed for your specific condition.