Key takeaways
Climara (estradiol) and Evamist (estradiol) are both estrogen replacement therapies used to relieve menopausal symptoms like hot flashes and night sweats. Climara is a transdermal patch that you apply to your skin once or twice a week, while Evamist is a topical spray that you use daily on your forearm. Climara can also help prevent osteoporosis, but it might cause weight gain and requires you to avoid swimming if you use the once-weekly patch. Evamist dries quickly and doesn't need to be rubbed in, but it can be expensive since it's only available as a brand-name product. Both medications carry risks of serious side effects like blood clots, certain cancers, and gallbladder problems, and they are not safe if you have liver issues. If you have a uterus, you'll need to use a progestin with either medication to lower your risk of uterine cancer.
