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Compare Minivelle vs. Evamist

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Climara (estradiol) and Evamist (estradiol) are both estrogen replacement therapies used to relieve menopausal symptoms like hot flashes and night sweats. Climara is a transdermal patch that you apply to your skin once or twice a week, while Evamist is a topical spray that you use daily on your forearm. Climara can also help prevent osteoporosis, but it might cause weight gain and requires you to avoid swimming if you use the once-weekly patch. Evamist dries quickly and doesn't need to be rubbed in, but it can be expensive since it's only available as a brand-name product. Both medications carry risks of serious side effects like blood clots, certain cancers, and gallbladder problems, and they are not safe if you have liver issues. If you have a uterus, you'll need to use a progestin with either medication to lower your risk of uterine cancer.

  • Minivelle (estradiol patch)
    Evamist (estradiol)
  • Minivelle (estradiol patch)
    Evamist (estradiol)

  • Summary of Minivelle vs. Evamist

    Summary for Estrogen replacement
    Prescription only

    Minivelle (estradiol patch) is a twice-weekly hormonal patch that treats moderate-to-severe vasomotor symptoms, like hot flashes and night sweats, caused by menopause. It can also prevent bone loss (osteoporosis) after menopause. It's a type of hormone replacement therapy. The usual dose is one patch applied to the lower stomach or buttocks twice a week, or every 3 to 4 days. Potential side effects include headache, breast tenderness, and back pain.

    Summary for Estrogen replacement
    Prescription only

    Evamist (estradiol) is a topical hormone spray that helps relieve the hot flashes and night sweats caused by menopause. It's a hormone replacement therapy (HRT) that's sprayed onto the skin of your inner forearm once a day. The typical dose ranges from 1 to 3 sprays daily, depending on your symptoms. Some potential side effects of this medication include headache, tender breasts, and back pain.

  • Indications of Minivelle vs. Evamist

    Indications for
    •Hot flashes, night sweats, and flushes caused by menopause
    •Prevent osteoporosis that happens after menopause
    Indications for
    •Moderate-to-severe vasomotor symptoms of menopause, like hot flashes and night sweats

  • Pros and Cons of Minivelle vs. Evamist

    Pros and Const for Estrogen replacement
    Pros
    •Typically has fewer side effects than oral estrogen pills
    •Delivers a consistent dose of estrogen over time
    •Good option if you have trouble swallowing pills
    •Available in different strengths, allowing you to customize your dose
    Cons
    •Commonly causes headache, breast tenderness, and back pain
    •Need to apply a new patch twice a week
    •Raises your risk of certain cancers, blood clots, and strokes
    •Might need to take it with another hormone called progestin if you have a healthy uterus
    Pros and Const for Estrogen replacement
    Pros
    •Dries within 2 minutes, doesn't need to be rubbed in
    •Possible option if you can't swallow pills
    •Only needs to be applied once a day
    Cons
    •Raises your risk of certain cancers, blood clots, and strokes
    •Need to use with progestin to lower your risk of uterine cancer (in females who have uterus)
    •Must cover with clothing to prevent exposure to others

  • Common Side Effects of Minivelle vs. Evamist

    Common Side Effects for
    •Headache (up to 50%)
    •Common cold symptoms (up to 20%)
    •Breast tenderness (up to 17%)
    •Sinus swelling (up to 13%)
    •Bleeding in-between periods (up to 11%)
    •Depression (up to 11%)
    •Back pain (up to 11%)
    •Sinus headache (up to 10%)
    •Indigestion (up to 9%)
    •Weight gain (up to 9%)
    •Joint pain (up to 9%)
    Common Side Effects for
    •Headache (up to 12%)
    •Breast tenderness (up to 7%)
    •Nipple pain (up to 7%)
    •Cold-like symptoms (up to 5%)
    •Back pain (up to 5%)
    •Joint pain (up to 4%)

  • Warnings of Minivelle vs. Evamist

    Common Side Effects for
    •Blood clots and related complications (e.g., heart attack, stroke)
    •Uterine (endometrial) cancer
    •Breast cancer
    •Ovarian cancer
    •Dementia
    •Gallbladder and liver problems
    •Vision problems
    •High triglycerides
    •Low thyroid hormone levels (hypothyroidism)
    •Fluid Retention
    •Severe allergic reactions
    •Worsening of other health conditions
    Common Side Effects for
    •Uterine or endometrial cancer
    •Breast cancer
    •Blood clots, heart attacks, and strokes
    •Risk of dementia
    •Risk of harm in children (accidental contact with medication)
    •Gallbladder problems
    •Higher risk of side effects
    •Vision problems
    •High triglycerides
    •Changes in calcium levels in the blood
    •Low thyroid hormone levels (hypothyroidism)
    •Swelling from fluids
    •Worsening of other medical conditions

  • Prices with our coupons for Minivelle vs. Evamist

    Learn more about Minivelle
    Learn more about Evamist

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