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Activella vs. Divigel

Activella is a combination hormone replacement therapy (HRT) that contains estradiol (an estrogen) and norethindrone (a progestin). It's used to treat certain symptoms of menopause, such as night sweats and vaginal dryness, related to low estrogen levels. It can also help prevent bone loss (osteoporosis) in females who've reached menopause. The typical dose is 1 tablet by mouth once daily. Some side effects of this medication include breast pain and headache. Activella (estradiol / norethindrone), as well as other HRTs, isn't recommended for people who've had breast cancer.

Activella is a brand-name medication. It also comes as a generic and branded generics, such as Mimvey.

In females who have a healthy uterus:

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe symptoms of vulvar and vaginal atrophy, like vaginal dryness
• Prevention of osteoporosis in females who've reached menopause

• Breast pain (17-24%)
• Headache (11-17%)
• Accidental injury (3-17%)
• Upper respiratory tract infection, like cough, cold, sore throat, congestion (10-15%)
• Sinus infection (7-15%)
• Postmenopausal bleeding (10-11%)
• Nausea (10-11%)
• Weight gain (up to 9%)
• Ovarian cyst (up to 7%)
• Stomach flu (up to 6%)
• Viral infection (up to 6%)
• Vaginal yeast infection (up to 6%)
• Mood swings (up to 6%)
• Back pain (3-6%)

• Blood clots, heart attacks, and strokes
• Breast cancer
• Uterine or endometrial cancer
• Dementia
• Ovarian cancer
• Liver or gallbladder problems
• Changes in calcium levels in the blood
• Vision problems
• High triglyceride (fat) levels
• Low thyroid hormone levels
• Buildup of fluids in your body (fluid retention)
• Worsening of other medical conditions

Estradiol gel (Divigel) is a hormone replacement therapy used to treat symptoms of menopause, such as hot flashes and night sweats. It comes as single-use packets, and the dose is applied to the skin on your upper thigh once a day. The gel is available as both a brand-name and a generic medication. Common side effects include vaginal yeast infections, breast tenderness, and abnormal vaginal bleeding.

• Hot flashes and night sweats due to menopause

• Abnormal vaginal bleeding (4-10%)
• Breast tenderness (3-9%)
• Common cold symptoms (4-6%)
• Upper respiratory tract infection (2-6%)
• Vaginal yeast infection (1-6%)

• Risk of blood clot
• Uterine (endometrial) cancer
• Breast cancer
• Dementia
• Gallbladder and liver problems
• Changes in calcium levels in the blood
• Vision problems
• High triglycerides
• Low thyroid hormone levels (hypothyroidism)
• Fluid Retention
• Worsening of other medical conditions
• Potential skin-to-skin transfer