Key takeaways
Medroxyprogesterone (Provera) and estradiol (Vivelle-Dot) are both hormone therapy medications, but they belong to different classes and have different uses. Medroxyprogesterone is a progestin that helps regulate menstrual cycles and protects the uterus in postmenopausal women taking estrogen. Estradiol is an estrogen replacement used to treat menopause symptoms and prevent bone loss (osteoporosis) after menopause. Medroxyprogesterone is taken orally for 5 to 14 days each month, whereas estradiol is a patch applied to the lower stomach or upper buttocks twice a week. Common side effects of medroxyprogesterone include spotting and nausea, while estradiol can cause headaches and breast tenderness. Both medications carry risks of blood clots and cancer, especially when used together or with other hormone therapy.
