Key takeaways
Estring (estradiol) and Provera (medroxyprogesterone) are both prescription medications used for different purposes related to menopause and hormone balance. Estring is a vaginal ring that you insert into your vagina that releases a steady amount of estrogen to relieve vaginal dryness, burning, and irritation due to menopause. It needs to be replaced every 3 months. On the other hand, Provera is a progestin taken orally and is used to regulate menstrual periods and protect the uterus in postmenopausal women taking estrogen replacement therapy. Provera is taken daily for a specific number of days each month. Estring is only available as a brand-name medication, while Provera has a generic form. Estring works directly locally in the vagina and can cause vaginal-related side effects such as yeast infections, pain, or discomfort. Provera works systemically to balance hormone levels and can cause spotting or breakthrough bleeding, even in individuals who have gone through menopause. Both medications have serious risks, including blood clots and cancer, especially when used long-term or in combination with other hormone therapies.
