Key takeaways
Vivelle-Dot (estradiol patch) and Divigel (estradiol gel) are both estrogen replacement therapies used to treat menopause symptoms like hot flashes and night sweats. They are in the same medication class and work by replacing the estrogen your body loses during menopause. However, they differ in their application methods and dosing schedules. Vivelle-Dot is a transdermal patch applied to the lower stomach or buttocks twice a week, while Divigel is a topical gel applied to the upper thigh once a day. Vivelle-Dot is available as a generic called Dotti, and Divigel also has a generic version. Common side effects of Vivelle-Dot include headaches and breast pain, while Divigel may cause vaginal yeast infections and breast tenderness. Both medications can increase the risk of blood clots, certain cancers, and other serious health issues, so it's important to discuss these risks with your healthcare provider. You should apply the Vivelle-Dot patch to your lower stomach or buttocks, avoiding the waistline to prevent the patch from falling off.
